CTGF/CCN2 Promotes Invasive Growth in Cervical Cancer Spheroids and Is Associated With Metastatic Cervical Cancer Tissue. [PDF]
VON DER Brelie L +3 more
europepmc +1 more source
Ir Complexes With Mixed‐Valent Bidentate Ligands: From Complex Synthesis to Catalytic Application
ABSTRACT The bidentate ligands Ph2P(E)NHPPh2 (E = S, Se) feature phosphorous atoms in two different oxidation states and provide the potential to tune chemical reactivity through the choice of donor E. The mononuclear complexes [Ir(COD){κ2‐P,E‐Ph2P(E)NPPh2}] (E = S 1a, Se 1b) were prepared from the dimer [IrClCOD]2 (COD = 1,5‐cyclooctadiene) and the ...
C. Gabriela Morales Salas +4 more
wiley +1 more source
Claudin 18 Immunohistochemistry Expression in Salivary Gland Neoplasms: Limited Potential as a Therapeutic Biomarker. [PDF]
Fye N, Bhele S.
europepmc +1 more source
Naphthalene diimide–N‐heterocyclic carbene iridium complexes display uncommon multistimuli‐responsive behavior combining strong Cl(lp)···π interactions, ligand non‐innocence, visible‐light photoreduction, and conPET photocatalysis. The study also provides new insight into the interaction of NDI platforms with fluoride/basic anions, revealing unexpected
Maite Silva‐Muñoz +2 more
wiley +1 more source
Incidence of Invasive Pneumococcal Disease in US Children by Risk Group, 1998-2023. [PDF]
Mohanty S +13 more
europepmc +1 more source
C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens +3 more
wiley +1 more source
Metformin-Functionalized Selenium Nanoparticles Restore Insulin Signaling and Metabolic Homeostasis in Letrozole-Induced Polycystic Ovary Syndrome Rat Model. [PDF]
Ermis U +5 more
europepmc +1 more source
Trends and Future Directions in Organic Chemistry for Drug Discovery
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
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Targeting the IRE1α/XBP1 pathway in type 2 diabetes mellitus: from ER stress signaling to therapeutic opportunity. [PDF]
Obafemi OT +6 more
europepmc +1 more source
A Naphthalenediimide–Imidazolium Macrocycle for Orthogonal Molecular Recognition
One host, two recognition modes: a naphthalenediimide–imidazolium macrocycle switches between π‐driven encapsulation and hydrogen‐bonding to bind structurally diverse molecular and metal‐complex guests. ABSTRACT A naphthalenediimide‐imidazolium macrocycle is shown to function as a dual‐site supramolecular host for orthogonal molecular recognition.
Joel Martínez‐Visiedo +2 more
wiley +1 more source

