Results 71 to 80 of about 159,439 (253)

Deep mutational scanning reveals EGFR mutations conferring resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945

open access: yesnpj Precision Oncology
Fourth-generation EGFR tyrosine kinase are in development to overcome common resistance mutations. We performed deep mutational scanning (DMS) of the EGFR kinase domain in the context of L858R by introducing a saturation library of ~17,000 variants into ...
Yueyang Wang   +14 more
doaj   +1 more source

Isaac Olsen – The First Missionary among the Sami People in Finnmark?

open access: yesNordlit: Tidsskrift i litteratur og kultur, 2019
This article deals with Isaac Olsen, a Norwegian who was an itinerant catechist and teacher among the Sami people in Finnmark, Northern Norway. The author claims that Isaac Olsen, as a forerunner to the Sami missionary Thomas von Westen, in fact was the ...
Liv Helene Willumsen
doaj   +1 more source

The Benjamin–Ono Equation in the Zero‐Dispersion Limit for Rational Initial Data: Generation of Dispersive Shock Waves

open access: yesCommunications on Pure and Applied Mathematics, EarlyView.
ABSTRACT The leading‐order asymptotic behavior of the solution of the Cauchy initial‐value problem for the Benjamin–Ono equation in L2(R)$L^2(\mathbb {R})$ is obtained explicitly for generic rational initial data u0$u_0$. An explicit asymptotic wave profile uZD(t,x;ε)$u^\mathrm{ZD}(t,x;\epsilon)$ is given, in terms of the branches of the multivalued ...
Elliot Blackstone   +3 more
wiley   +1 more source

In vitro electrical stimulation devices: practical framework for design, fabrication, and operation

open access: yesJournal of Biological Engineering
Background Electrical stimulation of cell culture systems has shown significant potential benefits, attracting growing interest in bioelectrical research and tissue engineering.
Gaurav Kulkarni   +4 more
doaj   +1 more source

Isaac Newton as a Probabilist

open access: yesStatistical Science, 2006
In 1693, Isaac Newton answered a query from Samuel Pepys about a problem involving dice. Newton's analysis is discussed and attention is drawn to an error he made.
openaire   +3 more sources

How Consumers Contest Legitimacy: Skepticism Toward Corporate Social Responsibility

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Consumer skepticism toward Corporate Social Responsibility (CSR) initiatives operates not only as an individual‐level response but also as a societal governance mechanism that disciplines firms and reshapes organizational legitimacy. Drawing on in‐depth interviews with consumers in an emerging Latin American economy, this study advances an ...
Francine Zanin Bagatini   +2 more
wiley   +1 more source

Grand Jury letter to Hon. Judge Isaac Parker, 1890

open access: yes, 2018
The grand jury wrote a report to Judge Isaac Parker in 1890. They record that they tried around 60 cases on introducing liquor to the Indian Territory.
Marshall, James (Jury Foreman); United States. District Court (Arkansas : Western District). Grand Jury
core  

Spatially Multiplexed Micro-Spectrophotometry in Bright Field Mode for Thin Film Characterization

open access: yesSensors, 2016
Thickness characterization of thin films is of primary importance in a variety of nanotechnology applications, either in the semiconductor industry, quality control in nanofabrication processes or engineering of nanoelectromechanical systems (NEMS ...
Valerio Pini   +6 more
doaj   +1 more source

Beyond goniometry: 3D digital twinning of droplets from a single image

open access: yesDroplet, EarlyView.
We present a method to produce physics‐informed three‐dimensional digital twins of droplets from a single image for wettability analyses. We validate the method with goniometry and demonstrate its capabilities with advancing‐receding contact angle measurements, irregularly shaped droplets, and multi‐droplet systems, indicating strong potential for in ...
Isaac Berk, Emilie Luong, H. Jeremy Cho
wiley   +1 more source

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