Results 1 to 10 of about 5,548 (180)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Needle detection and localisation for robot‐assisted subretinal injection using deep learning

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Subretinal injection is a complicated task for retinal surgeons to operate manually. In this paper we demonstrate a robust framework for needle detection and localisation in robot‐assisted subretinal injection using microscope‐integrated Optical Coherence Tomography with deep learning.
Mingchuan Zhou, Xiangyu Guo, Matthias Grimm, Elias Lochner, Zhongliang Jiang, Abouzar Eslami, Juan Ye, Nassir Navab, Alois Knoll, Mohammad Ali Nasseri   +9 more
wiley   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Fine‐Tuning NIR‐Absorbing BODIPYs for Photoacoustic Detection of Hypochlorous Ion (OCl−)

Chemistry – An Asian Journal, Volume 20, Issue 6, March 17, 2025.
High selectivity for hypochlorous ion over other competing reactive oxygen species was achieved by optimizing different regioisomers of conjugation‐extended, near‐infrared‐absorbing BODIPYs for photoacoustic imaging. Abstract Highly reactive oxygen and nitrogen species (ROS/RNS) play crucial roles in various pathological conditions.
Prosenjit Isar, Tarushyam Mukherjee, Tengfei Ji, Alexander Nellessen, Jean Michel Merkes, Fabian Kiessling, Magnus Rueping, Srinivas Banala   +7 more
wiley   +1 more source

Online monitored characterization of Phocaeicola vulgatus for organic acid production using anaerobic microtiter plate cultivations

Biotechnology Progress, Volume 41, Issue 2, March/April 2025.
Abstract Phocaeicola vulgatus (formerly Bacteroides vulgatus), an anaerobic gut bacterium, produces several organic acids. Research on P. vulgatus is still in its infancy. However, a detailed understanding of P. vulgatus growth and metabolism is essential for its assessment as an organic acid producer.
Laura Keitel, Benjamin Schick, Gino Pohen, Stanislav Yordanov, Jochen Büchs   +4 more
wiley   +1 more source

Employment of artificial intelligence for an unbiased evaluation regarding the recovery of right ventricular function after mitral valve transcatheter edge‐to‐edge repair

European Journal of Heart Failure, EarlyView.
Impact of mitral transcatheter edge‐to‐edge repair (M‐TEER) on left and right heart function. IQR, interquartile range; LA, left atrial; RVEF, right ventricular ejection fraction; sPAP, systolic pulmonary artery pressure; TAPSE, tricuspid annular plane systolic excursion. Abstract Aims Long‐standing severe mitral regurgitation (MR) leads to left atrial
Vera Fortmeier, Amelie Hesse, Teresa Trenkwalder, Márton Tokodi, Attila Kovács, Elena Rippen, Jule Tervooren, Michelle Fett, Gerhard Harmsen, Shinsuke Yuasa, Moritz Kühlein, Héctor Alfonso Alvarez Covarrubias, Moritz von Scheidt, Ferdinand Roski, Muhammed Gerçek, Tibor Schuster, N. Patrick Mayr, Erion Xhepa, Karl‐Ludwig Laugwitz, Michael Joner, Volker Rudolph, Mark Lachmann   +21 more
wiley   +1 more source

Routine‐data‐compatible quality indicators for the ambulatory care of osteoarthritis of the knee and hip: A systematic review

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Germany has high rates of total joint arthroplasty for osteoarthritis of the knee and hip. Ambulatory health interventions can affect the progression of these conditions and the need for total joint arthroplasty. Quality indicators and guideline recommendations facilitate the transparent measurement and demonstration of care quality ...
Tobias Bock, Ronja Flemming, Philip Bammert, Rüdiger von Eisenhart‐Rothe, Michael T. Hirschmann, Leonie Sundmacher   +5 more
wiley   +1 more source

Age is not a primary risk factor for ACL injury—A comprehensive review of ACL injury and reinjury risk factors confounded by young patient age

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Revision surgery after anterior cruciate ligament reconstruction (ACL‐R) is hypothesized to be the result of an interplay between factors associated with the anatomy, physiological characteristics and environment of the patient. The multifactorial nature of revision ACL‐R risk is difficult to quantify, and evidence regarding the independent ...
Bálint Zsidai, Ramana Piussi, Philipp W. Winkler, Armin Runer, Pedro Diniz, Riccardo Cristiani, Eric Hamrin Senorski, Volker Musahl, Michael T. Hirschmann, Romain Seil, Kristian Samuelsson   +10 more
wiley   +1 more source

3D virtual biopsy of in vivo pH and metabolism using PRESS and semi‐LASER MRS of hyperpolarized 13C nuclei

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To develop and evaluate sequences for multi‐voxel magnetic resonance spectroscopy using hyperpolarized molecules. Methods A standard single voxel PRESS sequence was extended to acquire multiple voxels consecutively. Its SNR was compared against a 2D FID‐CSI with both 1H and hyperpolarized 13C nuclei in phantoms and in a healthy mouse ...
Wolfgang Gottwald, Luca Nagel, Martin Grashei, Sebastian Bauer, Nadine Setzer, Florian Gaksch, Sandra Sühnel, Jason G. Skinner, Rickmer Braren, Irina Heid, Geoffrey J. Topping, Franz Schilling   +11 more
wiley   +1 more source

B0 navigator enables respiratory motion navigation in radial stack‐of‐stars liver Look‐Locker T1 mapping

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To develop a B0$$ {B}_0 $$ self‐navigation approach to estimate respiratory motion for motion‐corrected liver T1$$ {T}_1 $$ mapping using a Look‐Locker acquisition with radial stack‐of‐stars trajectory. Methods The proposed method derives 1D field‐map profiles from the oversampled k‐space center to estimate a normalized breathing curve
Jonathan Stelter, Kilian Weiss, Veronika Spieker, Julia A. Schnabel, Rickmer F. Braren, Dimitrios C. Karampinos   +5 more
wiley   +1 more source