Results 41 to 50 of about 24,462 (279)

Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique

open access: yesNature Communications, 2019
Reversible cysteine modifications play important roles in cellular redox signaling. Here, the authors develop a chemical proteomics strategy that enables the quantitative analysis of endogenous cysteine nitrosylation sites and their dynamic regulation ...
Ruzanna Mnatsakanyan   +5 more
doaj   +1 more source

Hardware Acceleration of Stochastic Neural Networks Enabled by Bit‐Cell Level Co‐Design of Magnetic Tunnel Junctions

open access: yesAdvanced Science, EarlyView.
An MTJ‐based probabilistic processing‐in‐memory architecture unites nonvolatile storage, local entropy generation, and stochastic computation within each memory cell. Stored multi‐bit weights are converted directly into programmable stochastic bitstreams, enabling neural‐network inference, adaptive Ising optimization, and uncertainty‐aware Bayesian ...
Qiuyuan Wang   +6 more
wiley   +1 more source

Designing Wire Mazes for Replicating Natural Echoes to Study Bat Biosonar Function

open access: yesAdvanced Intelligent Systems, EarlyView.
A validated framework combining efficient physical modeling (multiple scattering model) and deep learning is presented to guide wire‐maze design for bat biosonar studies. This approach rapidly generates large datasets to test acoustic distinguishability among wire arrangements.
Chunlin Jia   +3 more
wiley   +1 more source

Ryugu’s Anhydrous Ingredients and Their Spectral Link to Primitive Dust from the Outer Solar System

open access: yesThe Astrophysical Journal Letters, 2023
Ryugu is a second-generation C-type asteroid formed by the reassembly of fragments of a previous larger body in the main asteroid belt. While the majority of Ryugu samples returned by Hayabusa2 are composed of a lithology dominated by aqueously altered ...
R. Brunetto   +39 more
doaj   +1 more source

Outcomes of Patients With AL Amyloidosis and End‐Stage Renal Disease After Initiation of Therapy

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT In AL amyloidosis, advanced renal disease can impact treatment options and cause significant morbidity. Patients with ESRD requiring dialysis are a group with currently unmet needs. In this collaborative study, we identified 362 patients from three European centers who initiated dialysis during the course of the disease.
Foteini Theodorakakou   +10 more
wiley   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation. [PDF]

open access: yesJ Sci Food Agric
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Bencsik T   +6 more
europepmc   +2 more sources

Recent Non‐Suicidal Self‐Injury in Autistic Adolescents and Adults: Characteristics, Clinical Correlates and Suicidal Thoughts and Behaviors

open access: yesAutism Research, EarlyView.
ABSTRACT Non‐suicidal self‐injury (NSSI) is prevalent among autistic adolescents and adults, yet research on its clinical characteristics, functions, and association with suicidal thoughts and behaviors (STBs) in this population remains limited. This study compared these domains between autistic adolescents and adults with and without recent NSSI.
Safaa Eldeeb   +7 more
wiley   +1 more source

Analysis of the dispersion of the ISAs with respect to the ASA, represented as the confidence ellipsoid.

open access: yes, 2022
Analysis of the dispersion of the ISAs with respect to the ASA, represented as the confidence ellipsoid.
Maxim Vochten (13970330)   +4 more
core   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden   +3 more
wiley   +1 more source

Sub-Pixel Classification of MODIS EVI for Annual Mappings of Impervious Surface Areas

open access: yesRemote Sensing, 2016
Regular monitoring of expanding impervious surfaces areas (ISAs) in urban areas is highly desirable. MODIS data can meet this demand in terms of frequent observations but are lacking in spatial detail, leading to the mixed land cover problem when per ...
Narumasa Tsutsumida   +4 more
doaj   +1 more source

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