Results 191 to 200 of about 1,043,947 (356)

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

Acute Reduction in Blood Flow in the Right Coronary Artery After PCI Facilitates Pacemaker-Induced Ventricular Fibrillation. [PDF]

Ann Noninvasive Electrocardiol
Wu B, Chen Y, Tang J, He J.
europepmc   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

The CCL11-CCR3 Axis Regulates the Aggravation of Neuroinflammation in Astrocytic Necroptosis After Cerebral Ischemia. [PDF]

FASEB J
Yin H, Zhang X, Li M, Liu Y, Zhang Y, Zhang Y, Ci H, Li K, Yang S, Wang G, Zhang T.   +10 more
europepmc   +1 more source

A peroxynitrite decomposition catalyst prevents mechanical allodynia and NMDA receptor activation in the hind-paw ischemia reperfusion injury rats

, 2013
Kyung Hwa Kwak, Hoon Jung, Jun Mo Park, Jinseok Yeo, Hyunjee Kim, Hyung‐Chul Lee, Sung Hye Byun, Jong-Chan Kim, Sung-Sik Park, Dong Gun Lim   +9 more
openalex   +2 more sources

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

Research progress on the mechanisms related to myocardial injury in rats with myocardial ischemia-reperfusion injury treated by acupuncture at neiguan (PC6) acupoint: A narrative review. [PDF]

Medicine (Baltimore)
Xin Q, Gao Z, Guo J, Wang Y, Zhang Z, Liu Y, Yang B, Sun J.   +7 more
europepmc   +1 more source

Electroacupuncture alleviates cerebral ischemia and reperfusion injury via modulation of the ERK1/2 signaling pathway

, 2016
Meihong Shen, Xiaolu Jin, Pengfei Li, Chunbing Zhang, Jinping Wu, Xi-lian Feng, Ying Zhang   +6 more
openalex   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

The Duodenum Under Duress: Unmasking Isolated Duodenal Hypoperfusion After Kidney Transplantation. [PDF]

Cureus
Veldi D, Mittal VV, Govinda Narayanareddy D, Verma V.   +3 more
europepmc   +1 more source