Results 231 to 240 of about 999,788 (310)

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Digital Ischemia as a Rare Initial Presentation of Myeloperoxidase (MPO)-Anti-neutrophil Cytoplasmic Antibody (ANCA)-Positive Granulomatosis With Polyangiitis: A Case Report. [PDF]

Cureus
Penaflor RK, Ong J, Phan M, Afroz S.
europepmc   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Antihypertensive and anti-ischemic effects of diltiazem in patients with primary hypertension. [PDF]

Medicine (Baltimore)
Zeng S, Chen T, Weng L, Zhu C.
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

A translational mechanistic synthesis of ischemia-reperfusion injury in experimental flap models toward free flap salvage. [PDF]

Front Surg
Akdemir O.
europepmc   +1 more source

Balancing Time and Risk: Temporary Arterial Occlusion in Middle Cerebral Artery Aneurysm Surgery. [PDF]

Brain Sci
Geiger P, Preuss-Hernandez C, Pinggera D, Thomé C, Petr O.   +4 more
europepmc   +1 more source

The immune-cardiovascular metabolic circuitry in myocardial ischemia-reperfusion injury: from metabolic signal release to spatiotemporal reprogramming. [PDF]

Front Immunol
Tan C, Zhou J, Li J, Zhang X, Yuan W.
europepmc   +1 more source