Results 171 to 180 of about 120,857 (300)

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Imaging application in ventricular arrhythmia of ischemic cardiomyopathy: diagnosis, treatment and prognosis. [PDF]

Echo Res Pract
Hu F, Tang T, Wang P, Gu G, Xue L.
europepmc   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Hypoxia conditioned adipose-derived stem cell-derived extracellular vesicle therapy improves cardiac function in a rat model of ischemic cardiomyopathy. [PDF]

Regen Ther
Kumagai K, Kawamura T, Torigata K, Harada A, Kishimoto Y, Miyagawa S, Yoshikawa Y.   +6 more
europepmc   +1 more source

Patients Experiencing Unsuccessful Defibrillation From Implantable Cardiac Devices Remain at Elevated Risk Despite Procedural Management

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Unsuccessful defibrillation therapy in patients with implantable cardiac defibrillators (ICDs) and ventricular tachytherapies may occur due to patient and/or device‐related factors; appropriate management strategies after failed defibrillation therapy have been incompletely described.
Nathaniel Christian‐Miller, Muazzum Shah, Kelly Arps, Amrish Deshmukh, Jackson Liang, Ryan Cunnane, Krit Jongnarangsin, Frank Pelosi, Hakan Oral, Michael Ghannam   +9 more
wiley   +1 more source

The Resynchronization Effect in Left Bundle Branch Pacing Can be Evaluated Non‐Invasively With the Implementation of Lead V8

Journal of Cardiovascular Electrophysiology, EarlyView.
The negative derivative activation time (NDAT) of the surface electrode positioned at V8 closely corresponds to the left ventricular electrical delay to the left ventricular lead within the coronary sinus during intrinsic rhythm, and during all left bundle branch area pacing subtypes (right ventricular septal pacing (RVSP), deep septal pacing (DSP ...
Vadivelu Ramalingam, Johan van Koll, Peter Tai, Vidal Essebag, Atul Verma, Uyên C. Nguyên, Joost Lumens, Justin G. L. M. Luermans, Kevin Vernooy, Jacqueline Joza   +9 more
wiley   +1 more source

Altered Carnitine Metabolism in Ischemic and Non-Ischemic Cardiomyopathy: A Comparative Metabolomics Study Using LC-MS/MS. [PDF]

Metabolites
Behram Kandemir Y, Güntekin Ü, Tosun V, Koyuncu İ, Yüksekdağ Ö.   +4 more
europepmc   +1 more source

Clinical Prediction Model for Unsuccessful Left Bundle Branch Area Pacing

Journal of Cardiovascular Electrophysiology, EarlyView.
A clinical prediction model based on NIVCD, interventricular septal thickness, and right atrial area enables individualized estimation of unsuccessful LBBAP and may help guide procedural strategy. ABSTRACT Introduction Left bundle branch area pacing (LBBAP) has rapidly become a preferred form of cardiac physiologic pacing; however, predictors of ...
Yousaku Okubo, Junji Maeda, Shogo Miyamoto, Hiroshi Oe, Naoki Ishibashi, Shunsuke Ishida, Takumi Sakai, Naoto Oguri, Motoki Furutani, Shunsuke Miyauchi, Sho Okamura, Takehito Tokuyama, Noboru Oda, Yukiko Nakano   +13 more
wiley   +1 more source

Exercise prescriptions for ischemic cardiomyopathy: a scoping review. [PDF]

Heart Fail Rev
Koskina L, Huerta NH, Rao SJ, Amin A.
europepmc   +1 more source

Impact of Left Bundle Branch Area Pacing on Echocardiographic Parameters and Symptoms: Data From the Conduction System Pacing Italian Network Group (C‐SING) Study

Journal of Cardiovascular Electrophysiology, EarlyView.
Left bundle branch area pacing is associated with preservation of ventricular function in patients with bradycardia indications and with significant reverse remodeling and symptomatic improvement in patients with heart failure. Maintaining a high percentage of effective LBBAP capture is critical to minimize the risk of pacing‐induced cardiomyopathy and
Gabriele Dell'Era, Pietro Palmisano, Daniela Dugo, Francesco Raffaele Spera, Alessandro Paoletti Perini, Gianluca Mirizzi, Luca Poggio, Luca De Mattia, Amato Santoro, Massimo Magnano, Matteo Baroni, Francesco Solimene, Davide Castagno, Donatella Ruggiero, Luca Tomasi, Antonio Rapacciuolo, Marcello Giudice, Giovanni Rovaris, Aldo Coppolino, Renzo Venanzio Iulianella, Valerio Giordano, Alessandra Tordini, Erika Taravelli, Gennaro Miracapillo, Enrico Boggio, Mario Volpicelli, Paolo Sabbatani, Francesco Pentimalli, Gianluca Manzo, Leonardo Marinaccio, Paola Napoli, Daniele Giacopelli, Giuseppe Patti   +32 more
wiley   +1 more source