Results 231 to 240 of about 119,611 (303)

Downregulation of SENP1 impairs nuclear condensation of MEF2C and deteriorates ischemic cardiomyopathy. [PDF]

Clin Transl Med
Xie Y, Li Q, Bian X, Yin Y, Liang Z, Liu X, Zhang T, Liu X, Quan X, Wang Y.   +9 more
europepmc   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

A NADH Oxidase Nanozyme Restores Redox Homeostasis to Ameliorate Multi-Organ Aging and Ischemic Cardiomyopathy. [PDF]

Research (Wash D C)
Chen Y, Liang Y, Shen J, Wang Y, Qiu B, Hou H, Qiu X.   +6 more
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial. [PDF]

Am J Cardiovasc Drugs
Yu X, Xu J, Cao J, Xu Q, Chen H, Yu D, Yao X, Chen K, Ma L.   +8 more
europepmc   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Understanding of the characteristics of fibroblasts in ischemic cardiomyopathy using single-nucleus RNA sequencing. [PDF]

Sci Rep
Zhang Q, Cai Z, Zhang Y.
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Ventricular Duration Map Area as a Valuable and Effective Target for VT Ablation End Point in Ischemic Cardiomyopathy: The VEDUM FREEDOM Study. [PDF]

Circ Arrhythm Electrophysiol
Cauti FM, Rossi P, Magnocavallo M, Polselli M, Martini N, Fioravanti F, Tanese N, Della Rocca DG, Spiriti G, Rampa L, Calore F, Donadello G, Del Greco A, Bondavalli B, Bisceglia C, Bisignani A, Iaia L, Scalisi G, Peretto G, Barengo A, Piccirillo G, Bianchi S, Della Bella P.   +22 more
europepmc   +1 more source

Comparative analysis of implantable cardioverter-defibrillator efficacy in ischemic and non-ischemic cardiomyopathy in patients with heart failure. [PDF]

Sci Rep
Demir E, Köse MR, Şimşek E, Orman MN, Zoghi M, Gürgün C, Nalbantgil S.   +6 more
europepmc   +1 more source