Results 41 to 50 of about 4,586 (236)

Antitumor pharmacotherapy of colorectal cancer in kidney transplant recipients

Therapeutic Advances in Medical Oncology, 2019
Renal transplantation has become the sole most preferred therapy modality for end-stage renal disease patients. The growing tendency for renal transplants, and prolonged survival of renal recipients, have resulted in a certain number of post-transplant ...
Yuanyuan Fu, Chengheng Liao, Kai Cui, Xiao Liu, Wentong Fang   +4 more
doaj   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Optimization of SWCNT‐FET Biosensors by Aptamer Engineering and Toehold‐Mediated Strand Displacement

Advanced Science, EarlyView.
Aptamer‐based single‐walled carbon nanotube (SWCNT) field‐effect transistor (FET) biosensors are developed for label‐free, real‐time biomarker detection. Truncated DNA aptamers enhance sensitivity through improved conformational switching. A toehold‐mediated strand displacement (TMSD) strategy optimizes functionalization and simplifies fabrication. The
Haosen Miao, Tingting Zheng, Houlin Yu, Gririraj Manoharan, Gustavo Sant'Anna, Nicholas Bedfrod, Jorge L. Chávez, Chang‐Seuk Lee, Matteo Palma   +8 more
wiley   +1 more source

Investoren-Staat-Streitschlichtung (ISDS) aus ökonomischer Sicht : Notwendigkeit, Probleme, Perspektiven [PDF]

, 2019
Grenzüberschreitende Investitionen spielen eine entscheidende Rolle für Wachstum und Wohlstand. Für den Investor ergeben sich in Verbindung mit grenzüberschreitenden Investitionen jedoch Fragen bezüglich des Schutzniveaus der Investition.
Engelhardt, Jan
core   +1 more source

Reforming Shareholder Claims in ISDS

, 2023
ISDS stands alone in empowering shareholders to bring claims for reflective loss (SRL) – meaning claims over harms allegedly inflicted upon the company, but which somehow affect share value.
Zarra, Giovanni, Lee, Jaemin, Arato, Julian, Claussen, Kathleen   +3 more
core   +1 more source

China’s position on the reform of the investor-state dispute settlement under the return of the Calvo Doctrine

Cogent Social Sciences
The return of the Calvo Doctrine, which emphasizes the sovereignty of host states and the primacy of local legal remedies in resolving disputes involving foreign investors, has significant implications for the reform of the Investor-State Dispute ...
Jiaqi Song
doaj   +1 more source

AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling

Advanced Science, EarlyView.
This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi, Minying Low, Peng Xiu, Kresten Lindorff‐Larsen, Yong Wang   +4 more
wiley   +1 more source

Responding to Incorrect ISDS Decision-Making: Policy Options [PDF]

, 2020
Criticism of the quality of investor-State dispute settlement (ISDS) decision-making often focuses on inconsistency (comparing ISDS decisions), and less frequently, incorrectness (evaluating individual ISDS decisions on a standalone basis).
De Luca, A, Paparinskis, M, Feldman, M, Titi, C   +3 more
core  

A Short‐Cut Design Approach to Evaluate Reboiler Designs in Vapor Recompression Scenarios

Chemie Ingenieur Technik, EarlyView.
A short‐cut model framework that incorporates mechanical vapor recompression (MVR) requirements into reboiler design is presented, which is particularly beneficial during early process development with limited data or initial feasibility assessments.
Franziska Lais, Stephan Scholl, Katharina Jasch   +2 more
wiley   +1 more source

Non‐native introductions influence fish body size distributions within a dryland river

Ecosphere, 2016
A contemporary challenge in ecology is assessing the ecosystem effects of multispecies introductions. Quantifying shifts in body sizes, a common trait with which many per capita rates of ecosystems functioning scales, provide an important way forward ...
Keith J. Fritschie, Julian D. Olden
doaj   +1 more source