Results 71 to 80 of about 45,090 (263)

Automated detection and prediction of suicidal behavior from clinical notes using deep learning.

PLoS ONE
BackgroundDeep learning approaches have tremendous potential to improve the predictive power of traditional suicide prediction models to detect and predict intentional self-harm (ISH).
Brian E Bunnell, Athanasios Tsalatsanis, Chaitanya Chaphalkar, Sara Robinson, Sierra Klein, Sarah Cool, Elizabeth Szwast, Paul M Heider, Bethany J Wolf, Jihad S Obeid   +9 more
doaj   +1 more source

A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures.

PLoS ONE, 2015
In situ hybridization (ISH) is an extremely useful tool for localizing gene expression and changes in expression to specific cell populations in tissue samples across numerous research fields. Typically, a research group will put forth significant effort
Tessa M Grabinski, Andrew Kneynsberg, Fredric P Manfredsson, Nicholas M Kanaan   +3 more
doaj   +1 more source

Lung Cancer Patients Display Increased Expression of Bovine Meat and Milk Factor (BMMF) Proteins in Peritumor Alveolar Macrophages

International Journal of Cancer, EarlyView.
Plasmid‐like DNA sequences frequently found in bovine milk and serum have been proposed as infectious agents promoting indirect carcinogenesis. This multi‐omics study detected immune cells positive for these bovine meat and milk factors (BMMFs) in patients with lung cancer, with BMMF expression inversely correlated with smoking intensity.
Nives Cecere, Kristina Alikhanyan, Claudia Ernst, Lisa Häfele, Lars Feuerbach, Imke Grewe, Sumen Siqin, Karin Gunst, Gunjan Shukla, Veronika Frehtman, Claudia Tessmer, Florian Eichhorn, Michael Allgäuer, Alexander Brobeil, Ilse Hofmann, Barbara Leuchs, Marc A. Schneider, Timo Bund   +17 more
wiley   +1 more source

The Association Between Human Papillomavirus and Prostate Cancer: A Systematic Review and Meta‐Analysis

International Journal of Cancer, EarlyView.
ABSTRACT Human papillomavirus (HPV), the necessary cause of cervical cancer, is associated with an increased risk of other anogenital cancers. While HPV has frequently been detected in prostate specimens, its role in prostate carcinogenesis remains controversial. We synthesized and meta‐analyzed the epidemiological literature on the association between
Sarah Botting‐Provost, Kristy Ng, Cassandra Laurie, Rodrigo Noorani, Mariam El‐Zein, Eduardo L. Franco   +5 more
wiley   +1 more source

Analysis of individualized brain–gut association networks and transcriptional patterns in major depressive disorder

Interdisciplinary Medicine, EarlyView.
Individualized brain–gut association networks suggest potential neuropathological mechanisms in MDD and MDDSI. Multilevel brain–gut association changes involving HSV‐1 and inflammation may be relevant to MDD, whereas alterations related to insulin metabolism may play a potential role in the neuropathological mechanisms of MDDSI.
Wei Wang, Baoyuan Zhu, Yuanyuan Huang, Liqin Liang, Zhaobo Li, Yunheng Diao, Minxin Guo, Heng Zhang, Jing Zhou, Fengchun Wu, Kai Wu   +10 more
wiley   +1 more source

Bijections for the Shi and Ish arrangements

European Journal of Combinatorics, 2014
The {\sf Shi hyperplane arrangement} Shi(n) was introduced by Shi to study the Kazhdan-Lusztig cellular structure of the affine symmetric group. The {\sf Ish hyperplane arrangement} Ish(n) was introduced by Armstrong in the study of diagonal harmonics. Armstrong and Rhoades discovered a deep combinatorial similarity between the Shi and Ish arrangements.
Emily Leven, Brendon Rhoades, Andrew Timothy Wilson   +2 more
openaire   +2 more sources

Controlling Growth of Ultrasmall Sub‐10 nm Silver Nanoparticles From Cotinus coggygria Scop. Extract and Evaluation of Its In Vitro Anti‐Breast Cancer, Antioxidant and Antimicrobial Activity

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study highlights the potential use of Cotinus coggygria Scop. plant extract in a single‐step synthesis of biocompatible and ultrasmall AgNPs for in vitro applications. Herein, microscopic analyses revealed that AgNP exposure did not induce appreciable morphological changes in CRL‐4010 cells, whereas MCF‐7 and MDA‐MB‐231 cells exhibited ...
Ümran Ünüvar, Tuğba Nur Aslan, Suray Pehlivanoğlu, Kübra Ece Coşkuner   +3 more
wiley   +1 more source

Clinical and Cytogenomic Characterization of Three Patients With Distal 1q43q44 Deletion: Twin Sisters With a de novo Deletion and a Patient With der(1)t(1;21)(q43;q22.3)mat

Journal of Clinical Laboratory Analysis, EarlyView.
Distal 1q43q44 deletions lead to a consistent neurodevelopmental phenotype characterized by microcephaly, corpus callosum abnormalities, and developmental delay. Despite differences in genomic architecture, overlapping deletions affecting dosage‐sensitive genes such as AKT3, HNRNPU, and ZBTB18 define the core phenotype.
Ma. Guadalupe Domínguez‐Quezada, Horacio Rivera, Luis E. Figuera, Patricio Barros‐Núñez, José Luis Castrillo, Carlos Córdova‐Fletes, Thania Alejandra Aguayo‐Orozco   +6 more
wiley   +1 more source

Refining the Multivariable Predictive‐Prognostic PREDICTR‐OPC Model for Survival in Surgical Escalation for Oropharyngeal Squamous Cell Carcinoma

The Laryngoscope, EarlyView.
The PREDICTR‐OPC model is the only prognostic classifier for oropharyngeal squamous cell carcinoma (OPSCC) that also predicts surgical outcomes. This study demonstrates that removing survivin from the model preserves its prognostic and predictive performance, with comparable discrimination, calibration, and clinical utility across training and ...
Lauren L. Zhang, Caroline Kristunas, C. Max Robinson, Jill M. Brooks, Alice J. Sitch, Stuart C. Winter, Justin Weir, Paul Matthews, Terry M. Jones, Keith Hunter, Pawel Golusinski, Ketan A. Shah, Selvam Thavaraj, Catharine M. West, Syed Haider, Edward Odell, Paul Nankivell, Sandra V. von Zeidler, Hisham Mehanna   +18 more
wiley   +1 more source

Persistence of Hepatitis C RNA in Liver Allografts Is Associated with Histologic Progression Independent of Serologic Viral Clearance

Journal of Transplantation, 2009
Background. Hepatitis C virus (HCV) nondetectability in the liver may predict a sustained viral response (SVR) in patients with an end of treatment response. HCV RNA can be detected in liver tissue by in situ hybridization (ISH). Aim. To determine if HCV
M. Ghabril, R. C. Dickson, M. Krishna, R. Lloyd, J. Aranda-Michel, A. Keaveny, R. Satyanarayana, H. Bonatti   +7 more
doaj   +1 more source