High accuracy in detecting HER2‐low status in FNA of primary and metastatic breast cancer
ABSTRACT Background HER2‐positive invasive breast carcinomas (IBCs) account for 15% of breast cancers and are driven by ERBB2 gene amplification. Although historically associated with aggressive behavior, HER2‐targeted therapies have significantly improved outcomes.
Giuseppe D’Abbronzo +11 more
wiley +1 more source
Enhanced Quantitative Assessment of Lumbar Facet Joint Degeneration: Refining the Joint Degeneration Grading System With Grayscale Curve Fitting and Imaging Parameter. [PDF]
Liu X +6 more
europepmc +1 more source
Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu +9 more
wiley +1 more source
Unveiling the traits of HER2-low breast cancer: a comparative analysis of IHC1+ vs IHC2+/ISH-negative subgroups - insights from a 3-year cohort study. [PDF]
Correia J +14 more
europepmc +1 more source
Pulsatilla tongkangensis, an endemic species growing in the limited areas in Korea, is considered endangered species, and is growing in sympatric with P. koreana enabling natural hybridization. To characterize the true to the type of P. tongkangensis, we integrated morphological traits and molecular analyses of the nuclear ribosomal ITS (nrITS) and the
Hyun Min Kim +3 more
wiley +1 more source
RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a. [PDF]
Wang KT +6 more
europepmc +1 more source
FMD viral antigen was consistently associated with the vasculature of the coronary band and interdigital skin as well as in the lungs. The IHC results revealed a novel association of viral antigen with vascular tissue and demonstrated the potential for superior sensitivity over PCR. ABSTRACT Background African buffalo are long‐term carriers of foot‐and‐
Alischa Henning +3 more
wiley +1 more source
Serum HER2 extracellular domain as a predictive biomarker for trastuzumab deruxtecan treatment response in HER2-positive gastric cancer: a real-world study. [PDF]
Narita Y +10 more
europepmc +1 more source
This article examines how emerging generative AI technologies in Europe and North America are being used to reanimate the dead, prompting users to define the ‘edges’ of self and personhood through coding practices. These technologies invite new engagements with fundamental questions of relatedness and the construction of the self, challenging and ...
Jennifer Cearns
wiley +1 more source
Integrated genetic analyses identified T-cell neoplasms other than adult T-cell leukemia/lymphoma in HTLV-1 carriers. [PDF]
Naito Y +19 more
europepmc +1 more source

