Results 151 to 160 of about 45,260 (250)

MVB Maturation Responsive to KRASG12D/TP53R175H Co‐mutations Fuels Extracellular Vesicle‐hypersecretion Phenotype to Aggravate Lymphangiogenesis and Lymphatic Metastasis

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
KRAS/TP53 co‐mutation specifically induces transcriptional upregulation of FUS, which mediates EVs‐circSCARNA10 secretion to anchor lymphatic endothelial cells via promoting VEGFR3 transcription, ultimately inducing lymphangiogenesis and LN metastasis of KRASG12D and TP53R175H co‐mutated PDAC.
Jiabin Yang, Yuming Luo, Yu Zhou, Mingjie An, Mingrui Pang, Zhihua Li, Qingyu Xie, Hanhao Zheng, Zhou Fang, Yao Kong, Chao Yu, Yan Lin, Dingwen Zhang, Bingxin Cao, Haoming Zhong, Changhao Chen, Rufu Chen   +16 more
wiley   +1 more source

Mast cells and endothelial cells mediate interleukin-33 and ST2 responses in distal chronic obstructive pulmonary disease lungs. [PDF]

Am J Respir Crit Care Med
Andersson CK, Siddhuraj P, Jönsson J, Ahlgren J, Lindö C, Nys JA, Scott IC, Lindstedt S, Kolbeck R, Humbles AA, Lutter R, Sabogal Piñeros YS, Jonkers RE, Tufvesson E, Sandén C, Cohen ES, Erjefält JS.   +16 more
europepmc   +1 more source

Refining the Multivariable Predictive‐Prognostic PREDICTR‐OPC Model for Survival in Surgical Escalation for Oropharyngeal Squamous Cell Carcinoma

The Laryngoscope, Volume 136, Issue 10, Page 4290-4300, October 2026.
The PREDICTR‐OPC model is the only prognostic classifier for oropharyngeal squamous cell carcinoma (OPSCC) that also predicts surgical outcomes. This study demonstrates that removing survivin from the model preserves its prognostic and predictive performance, with comparable discrimination, calibration, and clinical utility across training and ...
Lauren L. Zhang, Caroline Kristunas, C. Max Robinson, Jill M. Brooks, Alice J. Sitch, Stuart C. Winter, Justin Weir, Paul Matthews, Terry M. Jones, Keith Hunter, Pawel Golusinski, Ketan A. Shah, Selvam Thavaraj, Catharine M. West, Syed Haider, Edward Odell, Paul Nankivell, Sandra V. von Zeidler, Hisham Mehanna   +18 more
wiley   +1 more source

Clinical benefit of various HER2-directed regimens in gastrointestinal malignancies: a retrospective cohort study. [PDF]

BMC Cancer
Khanna V, Vadde S, Henry AS, Johnson TP, Shaheen S, Heestand GM, Holden T, Chong CR, Goyal L, Fisher GA, Chen CT.   +10 more
europepmc   +1 more source

Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2‐Low Breast Cancer

MedComm, Volume 7, Issue 10, October 2026.
This prospective single‐arm study evaluated neoadjuvant disitamab vedotin plus penpulimab in 20 patients with Stage II–III HER2‐low breast cancer. The regimen showed preliminary activity (pCR 20.0% intention‐to‐treat, 25.0% evaluable; ORR 56.3%) with manageable toxicity.
Xiaoxiao Liu, Yuting Song, Lei Liu, Aaron Qi Zhang, Xin Xie, Bing Wei, Ping He, Chunying Zhuang, Juanjuan Li, Xi Yan, Tinglun Tian, Xiaorong Zhong, Jie Chen, Yan Cheng, Dan Zheng, Shibao Li, Hao Wang, Ting Luo   +17 more
wiley   +1 more source

CXCL14 is a novel biomarker for mast cell infiltration in the melanoma tumor microenvironment. [PDF]

J Dermatol Sci
Lietzau S, Cutler MC, Li M, Hejna M, Chung J, Kambe N, Song JS, Kawakami A, Kabashima K.   +8 more
europepmc   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan, Ke Tang, Linglong Wang, Qin Tian, Mingwei Zheng, Cheng Qian, Limei Liu   +6 more
wiley   +1 more source

Association between occupational hearing loss and predicted 10 year cardiovascular risk among middle aged industrial workers. [PDF]

PLoS One
Kassiri N, Eslami M, Labbafinejad Y, Harati M, Mohammadi S, Asadgol Z.   +5 more
europepmc   +1 more source

“I think people's perception that her reading is good enough. That would be a worry to me.” Mother and child perspectives of school‐related reading for children with Down syndrome

Journal of Research in Special Educational Needs, Volume 26, Issue 4, October 2026.
Abstract There is growing interest in children's reading experiences, both volitional and those initiated by, or connected to, school‐related reading. However, the majority of this research focuses on the reading experiences of neurotypical children; limiting understanding and the potential to improve support for other groups of children.
Katie Cebula, Sarah McGeown
wiley   +1 more source

Combinatorial mechanisms specify cellular location and neurotransmitter identity during planarian neurogenesis. [PDF]

Nat Commun
Clay KB, Medlock-Lanier T, Grimes RN, Oke OO, Hudson BT, Wilson MM, Filipov NM, Roberts-Galbraith RH.   +7 more
europepmc   +1 more source