Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang +7 more
wiley +1 more source
The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression. [PDF]
Bracken-Clarke D +20 more
europepmc +1 more source
Zebrafish Müller glia are heterogeneous in the early larval retina. Zebrafish Müller glia subtypes define a spatial axis of retinoic acid metabolism. Neuron‐associated glial programs identified in Zebrafish Müller glia are evolutionarily conserved in mammals. ABSTRACT Müller glia are instrumental macroglia of the vertebrate retina, once thought to be a
Samuel S. Storey +3 more
wiley +1 more source
Methodological Pitfalls in Endometriosis Biospecimen Research: Lessons From MAP4K4 Expression Studies. [PDF]
Badran D +7 more
europepmc +1 more source
ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo +6 more
wiley +1 more source
Case Report: Heterogeneous endoscopic and histological presentations of gastric and gastroesophageal metastases from breast carcinoma: a three-case series from a Malaysian tertiary center. [PDF]
Loo GH +6 more
europepmc +1 more source
ABSTRACT Most people living with HIV‐1 (HIV) are diagnosed during the chronic stage of infection, at which point viral setpoint has been established and a substantial immunopathologic damage in the secondary lymphatic tissues (LTs) has been induced. To better characterize virus‐host interaction and immunopathologic damage in LTs, we investigated viral ...
Yilun Cheng +5 more
wiley +1 more source
Frailty Prevalence and Related Factors among Older Adults in the Republic of Korea and the Need for Tailored Community-based Frailty Prevention Strategies. [PDF]
Hwang I, Park K, Park KS, Kim Y.
europepmc +1 more source
Liquid Biopsy: Past, Present, and Future
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu +8 more
wiley +1 more source
Next-Generation Immunohistochemical and RNA in Situ Hybridization Assays for Renal Neoplasia: Which Biomarkers Are Ready for Prime Time? [PDF]
Valk JE, Tretiakova MS.
europepmc +1 more source

