Results 51 to 60 of about 6,627,792 (217)

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Synthesis and Structures of Novel Chiral Cyclic Hypervalent Iodine(III) Reagents for Metal‐Free Ligand‐Transfer Reactions

Chemistry – A European Journal, EarlyView.
Several new chiral cyclic hypervalent iodine(III) reagents have been synthesized and characterized. Carbon‐based ligands were successfully installed onto the hypervalent iodine centers, giving thus access to novel chiral cyano‐, trifluoromethyl‐ or alkynyl‐bearing λ3‐iodanes.
Emmanuel Valzer, Jean‐Marc Sotiropoulos, Karinne Miqueu, Laurent Pouységu, Stéphane Quideau   +4 more
wiley   +1 more source

Assessment of Color Vision Among School Children: A Comparative Study Between The Ishihara Test and The Farnsworth D-15 Test

Journal of Nepal Medical Association, 2016
Introduction: Color vision is one of the important attribute of visual perception. The study was conducted at different schools of Kathmandu to compare the  ndings of the Ishihara Pseudoisochromatic test and the Farnsworth D-15 test.
Rajesh Kishor Shrestha, Gauri Shankar Shrestha   +1 more
doaj  

Comparison of a Smartphone Application with Ishihara Pseudoisochromatic Plate for Testing Colour Vision [PDF]

Neuro-Ophthalmology, 2018
The Eye Handbook (EHB) is the most frequently downloaded smartphone application with diagnostic tools for eye-care providers. However, limited data exists validating the EHB test to gold standard colour vision testing. EHB and Ishihara colour vision tests were evaluated and compared under simulated colour vision loss through use of image processing ...
Jiawei, Zhao, Michael Joseph, Fliotsos, Mehrnaz, Ighani, Allen O, Eghrari   +3 more
openaire   +2 more sources

Test Submission

, 2021
This is a sample submission generated by Vireo to test the repository deposit features.Test ...
Submitter, Test
core  

Evaluating the impact of an AI‐powered chatbot on epilepsy education and stigma reduction: A pre‐post intervention study using EpiloBot

Epilepsia Open, EarlyView.
Abstract Objective Effective epilepsy management requires accurate epilepsy knowledge, active patient engagement, and stigma reduction to improve health outcomes. Educational interventions have been shown to enhance patients' quality of life (QOL) and knowledge. This study evaluated the effectiveness of EpiloBot, an artificial intelligence (AI)‐powered
Izumi Kuramochi, Ryoya Oba, Naoki Nozawa, Tomoki Ishihara, Koko Oga, Takayuki Iwayama, Takafumi Shiganami, Sayaka Kobayashi, Hironori Kuga, Haruo Yoshimasu, Keiichi Watanuki   +10 more
wiley   +1 more source

Prevalence of congenital colour vision deficiency among secondary school students in Ibadan, South-West Nigeria

Nigerian Postgraduate Medical Journal, 2016
Aim: The aim was to determine the prevalence and pattern of congenital colour vision deficiency among secondary school students in Ibadan, Nigeria. Subjects and Methods: A descriptive cross-sectional study was conducted among students from three public ...
Mary Ogbenyi Ugalahi, Oluyemi Fasina, Olufunmilola A Ogun, Benedictus G K Ajayi   +3 more
doaj   +1 more source

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

Coloured filters can simulate colour deficiency in normal vision but cannot compensate for congenital colour vision deficiency

Scientific Reports, 2022
Red-green colour vision deficiency (CVD) affects ~ 4% of Caucasians. Notch filters exist to simulate CVD when worn by colour vision normal (CVN) observers (simulation tools), or to improve colour discrimination when worn by CVD observers (compensation ...
Leticia Álvaro, João M. M. Linhares, Monika A. Formankiewicz, Sarah J. Waugh   +3 more
doaj   +1 more source