Results 211 to 220 of about 1,742,725 (265)

Color Symmetry Breaking in a Nonlinear Optical Microresonator

open access: yesLaser &Photonics Reviews, EarlyView.
A two‐color pump drives an integrated microring resonator into spontaneous color symmetry breaking mediated by the nonlinear Kerr effect. Above threshold, one optical color becomes spontaneously dominant while the other is submissive, with the selected output state emerging randomly. These results establish a new form of symmetry breaking in integrated
Luca O. Trinchão   +10 more
wiley   +1 more source

Drive‐Efficient GHz‐Rate Binary‐State Updates Enabled by VCSEL Polarization Switching

open access: yesLaser &Photonics Reviews, EarlyView.
Photonic computing needs a compact node that can hold a binary state and update it fast. A vertical‐cavity surface‐emitting laser biased at its polarization‐switching point could serve as one: its two orthogonal linear polarizations are the two states, and a small electrical drive is enough to move the output from one state to the other at gigahertz ...
Zifeng Yuan   +6 more
wiley   +1 more source

Sex Differences in Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross‐Sectional Analysis

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Female sex is an independent fall risk factor in Parkinson's disease (PD), yet sex‐specific fall patterns remain unclear. Objectives To compare sex‐specific fall risk and outcomes across PD, prodromal alpha‐synucleinopathy (PAS), and healthy controls (HC); estimate fall frequency across PD progression; and assess how sex modifies ...
Joaquin A. Vizcarra   +197 more
wiley   +1 more source

Machine Learning Prediction of Hoehn and Yahr Scores at 5‐Years Post‐123I‐Ioflupane SPECT Imaging in a Real‐World Parkinson's Disease Dataset

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) progression is highly heterogeneous, complicating clinical management and prognostication. While machine learning models have been developed using research datasets such as Parkinson's Precision Medicine Initiative (PPMI) and Parkinson's Disease Biomarkers Program (PDBP), their clinical translatability is ...
Xuehua Ye   +9 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

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