Results 261 to 270 of about 20,721,849 (338)

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

open access: yesAdvanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen   +18 more
wiley   +1 more source

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

open access: yesAdvanced Science, EarlyView.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan   +12 more
wiley   +1 more source

Conformal invariance in the long-range Ising model [PDF]

open access: yes, 2015
M. Paulos   +3 more
semanticscholar   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu   +10 more
wiley   +1 more source

Dynamical Ising model of spatially coupled ecological oscillators. [PDF]

open access: yesJ R Soc Interface, 2020
Nareddy VR   +4 more
europepmc   +1 more source

UV‐Triggered Cascading Degradation of Silicone Elastomer via Self‐Fluoride Amplification

open access: yesAdvanced Science, EarlyView.
UV‐triggered degradable materials offer proficient control of functional lifetime, while having issues with trigger efficiency. This work enhances the UV‐triggered degradation mechanism of silicone elastomer by introducing the UV‐initiated synergetic fluoride self‐amplification. The silicone composite shows excellent mechanical properties and on‐demand
Yoon‐Nam Kim   +5 more
wiley   +1 more source

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