Results 71 to 80 of about 20,652,710 (339)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Eigenstate thermalization in the two-dimensional transverse field Ising model. [PDF]

open access: yesPhysical Review E, 2015
We study the onset of eigenstate thermalization in the two-dimensional transverse field Ising model (2D-TFIM) in the square lattice. We consider two nonequivalent Hamiltonians: the ferromagnetic 2D-TFIM and the antiferromagnetic 2D-TFIM in the presence ...
R. Mondaini   +3 more
semanticscholar   +1 more source

Energy trapped Ising model [PDF]

open access: yesPhysical Review D, 2020
In this paper we have considered the 3D Ising model perturbed with the energy operator coupled with a non uniform harmonic potential acting as a trap, showing that this system satisfies the trap-size scaling behavior. Eventually, we have computed the correlators $\langle (z) (0)\rangle$, $ \langle (z) (0)\rangle$ and $\langle (z) (0)\rangle$
Amoretti A.   +3 more
openaire   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

A GPU-Based Ising Machine With a Multi-Spin-Flip Capability for Constrained Combinatorial Optimization

open access: yesIEEE Access
Ising machines are domain-specific computers that solve combinatorial optimization problems (COPs). They utilize an Ising model to represent a COP and search for the optimal spin configuration of the Ising model to solve the COP.
Satoru Jimbo   +4 more
doaj   +1 more source

Flocking with discrete symmetry: The two-dimensional active Ising model. [PDF]

open access: yesPhysical review. E, Statistical, nonlinear, and soft matter physics, 2015
We study in detail the active Ising model, a stochastic lattice gas where collective motion emerges from the spontaneous breaking of a discrete symmetry.
A. Solon, J. Tailleur
semanticscholar   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

open access: yesFEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji   +3 more
wiley   +1 more source

Phase diagrams of lattice models on Cayley tree and chandelier network: a review

open access: yesCondensed Matter Physics, 2022
The main purpose of this review paper is to give systematically all the known results on phase diagrams corresponding to lattice models (Ising and Potts) on Cayley tree (or Bethe lattice) and chandelier networks.
H. Akιn
doaj   +1 more source

A Method of Riemann–Hilbert Problem for Zhang’s Conjecture 1 in a Ferromagnetic 3D Ising Model: Trivialization of Topological Structure

open access: yesMathematics, 2021
A method of the Riemann–Hilbert problem is applied for Zhang’s conjecture 1 proposed in Philo. Mag. 87 (2007) 5309 for a ferromagnetic three-dimensional (3D) Ising model in the zero external field and the solution to the Zhang’s conjecture 1 is ...
Osamu Suzuki, Zhidong Zhang
doaj   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

open access: yesFEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu   +9 more
wiley   +1 more source

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