Results 41 to 50 of about 12,049 (227)

Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation

Cell Reports, 2017
The development of therapeutic strategies to combat immune-associated diseases requires the molecular mechanisms of human Th17 cell differentiation to be fully identified and understood. To investigate transcriptional control of Th17 cell differentiation,
Subhash K. Tripathi, Zhi Chen, Antti Larjo, Kartiek Kanduri, Kari Nousiainen, Tarmo Äijo, Isis Ricaño-Ponce, Barbara Hrdlickova, Soile Tuomela, Essi Laajala, Verna Salo, Vinod Kumar, Cisca Wijmenga, Harri Lähdesmäki, Riitta Lahesmaa   +14 more
doaj   +1 more source

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus. [PDF]

PLoS ONE, 2016
In the fall of 2014, an international news agency reported that patients suffering from Ebola virus disease (EVD) in Liberia were treated successfully with lamivudine, an antiviral drug used to treat human immunodeficiency virus-1 and hepatitis B virus ...
Yu Cong, Julie Dyall, Brit J Hart, Lisa Evans DeWald, Joshua C Johnson, Elena Postnikova, Huanying Zhou, Robin Gross, Oscar Rojas, Isis Alexander, Nicole Josleyn, Tengfei Zhang, Julia Michelotti, Krisztina Janosko, Pamela J Glass, Mike Flint, Laura K McMullan, Christina F Spiropoulou, Tim Mierzwa, Rajarshi Guha, Paul Shinn, Sam Michael, Carleen Klumpp-Thomas, Crystal McKnight, Craig Thomas, Ann E Eakin, Kathleen G O'Loughlin, Carol E Green, Paul Catz, Jon C Mirsalis, Anna N Honko, Gene G Olinger, Richard S Bennett, Michael R Holbrook, Lisa E Hensley, Peter B Jahrling   +35 more
doaj   +1 more source

Archaeological Damage Assessment in Conflict Zones: Integrating Satellite Imagery and Ground Surveys in Daraa, Syria

Archaeological Prospection, EarlyView.
ABSTRACT Satellite remote sensing is among the most significant modern methodologies supporting field archaeology. In addition to its efficiency in identifying archaeological sites, remote sensing offers a safe and cost‐effective approach in conflict zones.
Amal Al Kassem, Kristen Hopper, Ismael M. Ibraheem, Andreas Maier, Mohammad Khair Nassrallah, Jürgen Richter   +5 more
wiley   +1 more source

The geopolitical implications of rare earth minerals extraction in Afghanistan

Journal of Trace Elements and Minerals
Background: Afghanistan’s Rare Earth Elements (REEs) reserves have become a central point of geopolitical competition following the Taliban’s return to power in 2021.
Ashraf Dawar, Muhammad Waqar Khan, Lindsey Tchatchouang   +2 more
doaj   +1 more source

Empowering citizens to spontaneously report suspected adverse drug reaction: Systematic literature review of interventions and their impact

British Journal of Clinical Pharmacology, EarlyView.
This systematic literature review aimed to identify and characterize existing interventions designed to empower citizens to spontaneously report adverse drug reactions (ADRs) and to determine which interventions have been shown to be the most effective internationally. The research question was structured using the PICO framework.
Margarida Perdigão, Ana Margarida Advinha, Manuel José Lopes, Sofia de Oliveira Martins   +3 more
wiley   +1 more source

Numerical Study of a Model and Full-Scale Container Ship Sailing in Regular Head Waves

Inventions
In the present study, the added resistance, heave, and pitch of the KRISO Container Ship (KCS) in waves, at both model scale and full scale, are predicted numerically in regular head waves, for four wavelengths and three wave heights.
Andreea Mandru, Liliana Rusu, Adham Bekhit, Florin Pacuraru   +3 more
doaj   +1 more source

Research Interviews in Historical Practice

Berichte zur Wissenschaftsgeschichte, EarlyView.
A key difference between collecting life stories and doing research interviews is the role of the interviewer. While training in oral history may focus on using standard scripts to take a life story, research interviews are motivated by specific questions that arise from particular historical projects and are often not primarily focused on the ...
Lara Keuck, Soraya de Chadarevian
wiley   +1 more source

Calcium retinoate nanoparticle mediated microglial polarization to regulate inflammatory microenvironment for therapy of neuroinflammatory disease

BMEMat, EarlyView.
A nano‐drug based on retinoic acid and calcium is developed, which can be rapily endocytosed by microglia and decomposed into small molecule/ion storms in lysosomes. This nano‐drug regulates microglial phenotype switching from M1 to M2 while indirectly guiding neuronal differentiation of endogenous neural stem cells, thereby ameliorating ...
Shuo Zhang, Yuan Yao, Wenfeng Shao, Jiapei Shi, Benjie Wei, Chunhui Sun, Jingang Wang, Jiaming Shi, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Na Ren, Yuchun Tang, Wenjuan Zhou, Shuping Wang   +13 more
wiley   +1 more source

Methods for the Construction and Editing of an Efficient Control Network for the Photogrammetric Processing of Massive Planetary Remote Sensing Images

Remote Sensing
Planetary photogrammetry remains an important technical means of producing high-precision planetary maps. High-quality control networks are fundamental to successful bundle adjustment.
Xin Ma, Chun Liu, Xun Geng, Sifen Wang, Tao Li, Jin Wang, Pengying Liu, Jiujiang Zhang, Qiudong Wang, Yuying Wang, Yinhui Wang, Zhen Peng   +11 more
doaj   +1 more source

Programmatic regulation of macrophage polarization by HAp@MXene nanocomposites to promote bone repair

BMEMat, EarlyView.
HAp@MXene nanocomposites could achieve the programmed regulation of macrophage polarization. They first induce M1 polarization through magnetoelectric induction to combat infection. Subsequently, controlled Ca2+ release drives M2 polarization to promote tissue regeneration. This dual mechanism accelerates bone defect repair and highlights the potential
Laisen Cui, Haina Huang, Yubo Zheng, Jiahao Zhang, Han Hai, Kai Bian, Zhichao Feng, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Shan Lu, Bojun Xie, Ke Gao, Benjie Wei, Ya Liu, Chunhui Sun, Hong Liu, Chao Liu   +16 more
wiley   +1 more source