Results 191 to 200 of about 1,109,260 (220)

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Testing the oceanic dispersal potential of Caribbean fleshy-fruited plants. [PDF]

PLoS One
Kim S, Montoya S, Tarazona-Tubens FL, Chavez C, Tucker Lima J, Olson D, Searcy C.   +6 more
europepmc   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Interannual differences in common eider duck exposure to avian influenza viruses at an Arctic colony. [PDF]

Conserv Physiol
Provencher JF, Morrill A, Hennin HL, Giacinti JA, Berhane Y, Zhmendak D, Xu W, Love OP, Forbes MR, Gilchrist HG.   +9 more
europepmc   +1 more source

Biogas production using the microbial community present in the soil from Deception Island, maritime Antarctica. [PDF]

Environ Sci Pollut Res Int
Ortigoza PYA, Luiz FN, Ghellere GJ, Meyer RF, Rosa LH, Passarini MRZ.   +5 more
europepmc   +1 more source

Evidence for Threshold-like Dynamics in <i>Aedes</i> Mosquito Populations Under Sustained Mass Trapping on Tropical Islands. [PDF]

Insects
Epple M, Rose A, Geier M, Knols BGJ.
europepmc   +1 more source

Dataset of field descriptions, physicochemical properties, and selective Fe-Al-Si extractions for 83 WRB-classified soil profiles (282 horizons) from tropical volcanic Réunion Island. [PDF]

Data Brief
Feder F.
europepmc   +1 more source

Inventory of arthropods (Arthropoda) through standardised protocols in the Teide National Park (Canary Islands, Spain). [PDF]

Biodivers Data J
Suárez D, Cárdenas M, Febles D, Jiménez-García E, Lugo D, Ruiz C, Macías-Hernández N.   +6 more
europepmc   +1 more source

Analyzing Trends in the Incidence of Trauma and Mechanisms of Injury Before, During, and After COVID-19 Lockdown in a Staten Island Level 1 Trauma Center. [PDF]

Cureus
Bogdanovski DA, Rubinshteyn V, Harrington T, LeBaron J, Cohen D, Issack PS, Basu A.   +6 more
europepmc   +1 more source