Results 11 to 20 of about 1,182,347 (214)
Lactylation-Driven PROS1-TYRO3-CARF Signaling Promotes Therapy-Induced Senescence Escape and Radioresistance in Meningioma. [PDF]
Adv Sci (Weinh)A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Wang Z +12 more
europepmc +2 more sources
Adenosine monophosphate-activated protein kinase activation is associated with suppression of NLRP3 inflammasome-mediated neuroinflammation in a weight-drop model of traumatic brain injury in Sprague-Dawley rats. [PDF]
Animal Model Exp MedThis graphical abstract illustrates the study's schematic model. Adenosine monophosphate–activated protein kinase (AMPK) activators exhibited neuroprotection in the weight‐drop model of traumatic brain injury by improving cognition and regulating oxidative stress, microglial activation, and nucleotide‐binding oligomerization domain, leucine‐rich repeat,
Kodi T +3 more
europepmc +2 more sources
Reconsidering Subextraction: Evidence from Spanish
Borealis: An International Journal of Hispanic Linguistics, 2014 This paper argues that so-called subextraction (e.g., Whoi has John seen a picture of ti ?; cf. Corver 2006 for recent discussion) does not involve movement of a wh-phrase to a DP internal escape hatch position before reaching the CP layer.
Ignacio Bosque, Ángel J. Gallego
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Au-delà de l’utopie : l’île comme révélateur de l’état socio-géopolitique du monde actuel
Carnets, 2019 The island is a geographical reality, an allegory, a position, an ideological space: a visual motif. This land surrounded by water becomes a dream projection surface for utopias and for the experience of these earthly paradises.
Alexandre Melay
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BMC Infectious Diseases, 2009 Background Some island nations have explicit components of their influenza pandemic plans for providing travel warnings and restricting incoming travellers. But the potential value of such restrictions has not been quantified.
Wilson Nick +3 more
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Evolutionary Applications, 2021 Introduced rodent populations pose significant threats worldwide, with particularly severe impacts on islands. Advancements in genome editing have motivated interest in synthetic gene drives that could potentially provide efficient and localized ...
Kevin P. Oh +11 more
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eLife, 2020 Pathogens find diverse niches for survival including inside a host cell where replication occurs in a relatively protective environment. Vibrio parahaemolyticus is a facultative intracellular pathogen that uses its type 3 secretion system 2 (T3SS2) to ...
Suneeta Chimalapati +11 more
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Humanities, 2022 In this essay I analyze the critically acclaimed movie, Birdboy: The Forgotten Children, a dystopic animated film based on the graphic novel Psiconautas.
Isabel Alvarez-Sancho
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Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. [PDF]
PLoS Genetics, 2007 The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal peripheral blood by methylated CpG ...
Lanlan Shen +9 more
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Evidence of long-term declines in Island Scrub-Jay vital rates
Avian Conservation and Ecology, 2021 Island species play important roles in local ecosystems, but they are undergoing unprecedented rates of extinction from a variety of threats including emerging infectious disease, invasive species, and climate change.
Brittany A. Mosher +4 more
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