Results 251 to 260 of about 45,050,096 (318)

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Hydrochemical and isotopic signatures of groundwater infiltration and legacy nitrogen discharge within Jeju Island aquaculture systems. [PDF]

Sci Rep
Kim SH, Park SE, Go YS, Kim CS, Kim C, Yang M, Kim T, Lee DH.   +7 more
europepmc   +1 more source

POSS Polyimide Composite Sealed Triple‐Junction GaAs Thin‐Film Solar Cell for Long‐Term Low Earth Orbit Serve

Advanced Science, EarlyView.
Ultrathin oxide layer and ultraviolet absorbent are introduced into polyhedral oligomeric silsesquioxane (POSS) polyimide to improve the transmittance conservation and realize near zero mass loss against ultraviolet and atomic oxygen exposures. The POSS polyimide composite sealed triple‐junction GaAs thin‐film solar cell exhibits enhanced endurance of ...
Min Qian, Min Wu, Xiaoyang Xuan, Yang Gao   +3 more
wiley   +1 more source

Mapping the Genomic Limits of De-Extinction in the Face of Ancient DNA Degradation. [PDF]

Genome Biol Evol
Lin J, Long X, Gao Y, Liu W, Gilbert MTP.   +4 more
europepmc   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Exponentially increasing microplastic accumulation in an urban estuary: insights from the Narragansett Bay, Rhode Island seafloor. [PDF]

Environ Sci Pollut Res Int
Fulfer VM, Walsh JP, Corbett DR.
europepmc   +1 more source

Unrecognized species-level diversity of terrestrial nemerteans in the UNESCO world heritage Ogasawara Islands revealed by mitogenomics. [PDF]

BMC Ecol Evol
Hookabe N, Hiruta SF, Yabuki A, Yoshino H, Hisasue Y, Sawada N, Ueshima R, Kajihara H.   +7 more
europepmc   +1 more source