Results 221 to 230 of about 358,941 (349)

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, Volume 15, Issue 12, Page 1987-2000, December 2025.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Vigor tests for evaluation of crambe (Crambe abyssinica Hochst) seed quality

Journal of Seed Science
The aim of this study was adapting the methodology of the accelerated aging test (AA) and electrical conductivity test (EC) to evaluate seed quality of crambe, as well as verifying enzymatic activity in relation to vigor differences. Crambe seed lots, cv.
Sara Michelly Cruz, Marcela Carlota Nery, Adriana de Souza Rocha, Édila Vilela de Resende Von Pinho, Paulo César de Resende Andrade, Denise Cunha Fernandes dos Santos Dias   +5 more
doaj  

Phenotype augmentation using generative AI for isocitrate dehydrogenase mutation prediction in glioma. [PDF]

Sci Rep
Jung HK, Choi C, Park JE, Park SY, Lee JH, Kim N, Kim HS.   +6 more
europepmc   +1 more source

Identification of Mn2+-binding Aspartates from α, β, and γ Subunits of Human NAD-dependent Isocitrate Dehydrogenase [PDF]

, 2006
Sambanthamurthy Soundar, Molly O’Hagan, Kenneth S. Fomulu, Roberta F. Colman   +3 more
openalex   +1 more source

Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Researchers discovered that fibronectin fibers lose their tension in specific areas of glioblastoma brain tumors, accumulating in the lumen of proliferating blood vessels and in parenchyma next to infiltrating immune cell clusters. A novel molecular tension probe enables the mapping of fibronectin's fiber tension in glioblastoma for the first time ...
Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel   +6 more
wiley   +1 more source

Severe Chemoradiotherapy Toxicity in a Pediatric Patient with Leigh Syndrome and Grade IV Isocitrate Dehydrogenase-Mutant Astrocytoma: A Case Report. [PDF]

Am J Case Rep
Granberry MT, Severance T, Biedermann G, Quinsey C, Mazuru DG, Bach A.   +5 more
europepmc   +1 more source

Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase

, 2016
Juliya Kalinina, Jun Young Ahn, Narra S. Devi, Liya Wang, Yuancheng Li, Jeffrey J. Olson, Michael Glantz, Thomas W. Smith, Ella L. Kim, Alf Giese, Randy L. Jensen, Clark C. Chen, Bob S. Carter, Hui Mao, Miao He, Erwin G. Van Meir   +15 more
openalex   +2 more sources

Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development.

Annual Review of Biochemistry, 2017
L. Dang, Shinsan M. Su
semanticscholar   +1 more source

Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Tumour metabolic reprogramming initiates a vicious cycle of immunosuppression and therapy resistance. This synergy disarms immunity and fortifies tumour cells, ultimately driving clonal evolution of resistant disease. Abstract Background Glucose metabolic reprogramming is a hallmark of cancer, best exemplified by the Warburg effect.
Li Ma, Ming‐yang Wu, Cui‐cui Tian, Hao‐ze Shi, Dan Song   +4 more
wiley   +1 more source

Habitat subregions analysis based on neurite orientation dispersion and density imaging enhances isocitrate dehydrogenase genotyping in glioma. [PDF]

BMC Med Imaging
Yang Z, Lin R, Wu Z, Song Y, Yang G, Jiang R, Xue Y, Wáng YXJ.   +7 more
europepmc   +1 more source