Results 221 to 230 of about 68,056 (282)

FDA Approval Summary: Olutasidenib for Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia with an Isocitrate Dehydrogenase 1 Mutation. [PDF]

Clin Cancer Res
Woods AC, Norsworthy KJ, Choe M, Gehrke BJ, Chen H, Vallejo J, Pan L, Jiang X, Li H, Kraft J, Liu J, Charlab R, Okusanya OO, Booth B, Pazdur R, Theoret MR, Angelo de Claro R.   +16 more
europepmc   +1 more source

A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH‐mutant gliomas

International Journal of Cancer, Volume 157, Issue 3, Page 573-587, 1 August 2025.
What's new? Isocitrate dehydrogenase (IDH)‐mutant gliomas typically affect young adults and invariably progress toward increasingly malignant phenotypes, despite treatment. Recurrence often is unpredictable, however, indicating a need for a deeper understanding of factors that drive disease return.
Tiffanie Chouleur, Christèle Etchegaray, Laura Villain, Antoine Lesur, Thomas Ferté, Marco Rossi, Laetitia Andrique, Costanza Simoncini, Anne‐Sophie Giacobbi, Matteo Gambaretti, Egesta Lopci, Bethania Fernades, Gunnar Dittmar, Rolf Bjerkvig, Boris Hejblum, Rodolphe Thiébaut, Olivier Saut, Lorenzo Bello, Andreas Bikfalvi   +18 more
wiley   +1 more source

AI‐Enhanced Predictive Imaging in Precision Medicine: Advancing Diagnostic Accuracy and Personalized Treatment

iRADIOLOGY, Volume 3, Issue 4, Page 261-278, August 2025.
Schematic showing the process of AI‐assisted medical imaging. After symptom onset, the patient consults a doctor who recommends imaging. Image data are collected and processed using traditional or faster AI‐based methods. The AI‐enhanced images assist the radiologist in diagnosis and improve health outcomes.
Aswini Rajendran, Rithi Angelin Rajan, Saranya Balasubramaniyam, Karthikeyan Elumalai   +3 more
wiley   +1 more source

Integration of amide proton transfer-weighted imaging and methionine positron emission tomography histogram parameters enhances the prediction of isocitrate dehydrogenase mutations in adult diffuse gliomas. [PDF]

EJNMMI Rep
Kusunoki M, Isoda T, Yamashita K, Kitamura Y, Kikuchi K, Sando M, Baba S, Kuga D, Fujioka Y, Narutomi F, Yoshimoto K, Ishigami K, Togao O.   +12 more
europepmc   +1 more source

Imaging‐Based Molecular Characterization of Adult‐Type Diffuse Glioma Using Diffusion and Perfusion MRI in Pre‐ and Post‐Treatment Stage Considering Spatial and Temporal Heterogeneity

Journal of Magnetic Resonance Imaging, Volume 62, Issue 2, Page 468-479, August 2025.
ABSTRACT Background Imaging‐based molecular characterization is important for identifying treatment targets in adult‐type diffuse gliomas. Purpose To assess isocitrate dehydrogenase (IDH) mutation and epidermal growth factor receptor (EGFR) amplification status in primary and recurrent gliomas using diffusion and perfusion MRI, addressing spatial and ...
Yun Hwa Roh, E‐Nae Cheong, Ji Eun Park, Yangsean Choi, Seung Chai Jung, Sang Woo Song, Young‐Hoon Kim, Chang‐Ki Hong, Jeong Hoon Kim, Ho Sung Kim   +9 more
wiley   +1 more source

An INS‐1 832/13 𝛽‐Cell Proteome Highlights the Rapid Regulation of Fatty Acid Biosynthesis in Glucose‐Stimulated Insulin Secretion

PROTEOMICS, Volume 25, Issue 15, Page 13-26, August 2025.
ABSTRACT Pancreatic beta cells secrete insulin in response to rising glucose levels, a process known as glucose‐stimulated insulin secretion (GSIS). Here, we acquire proteomes of rat pancreatic INS‐1 832/13 beta cells that were short‐term stimulated with 11 different glucose concentrations from 0 to 20 mM, quantifying the response of 3703 proteins ...
Nina Stremmel, Oliver Lemke, Kathrin Textoris‐Taube, Daniela Ludwig, Michael Mülleder, Julia Muenzner, Markus Ralser   +6 more
wiley   +1 more source

Unlocking the Glioblastoma Enigma: Exploring PD-L1 (Programmed Death-Ligand 1) and IDH1 (Isocitrate Dehydrogenase-1) Expression and Their Immunotherapeutic Implications. [PDF]

Cureus
Mushir SI, Chaudry SS, Azmat H, Masood A, Habib M, Sheikh AK.   +5 more
europepmc   +1 more source

Psidium Defenses Against Meloidogyne enterolobii: Proteomic and Microscopic Analysis of this Plant‐Predator Association

PROTEOMICS, Volume 25, Issue 16, Page 17-27, August 2025.
ABSTRACT Guava (Psidium guajava), referred to as the “tropical apple,” is esteemed for its sweet flavor, nutritional density, and medicinal attributes, being rich in ascorbic acid, phenolics, carotenoids, fibers, and minerals. Despite its agricultural significance, guava cultivation faces considerable challenges from plant‐parasitic nematodes ...
Sara Nállia de Oliveira Costa, Roberta Pena da Paschoa, Camilla Ribeiro Alexandrino, Pamela Maciel Cremonez, Juliana Martins Ribeiro, José Mauro da Cunha e Castro, Maura Da Cunha, Vanildo Silveira, Antônia Elenir Amâncio Oliveira, Kátia Valevski Sales Fernandes   +9 more
wiley   +1 more source

Recent Advances in the Therapeutic Potential of Cannabinoids Against Gliomas: A Systematic Review (2022–2025)

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
Emerging mechanisms of cannabinoid‐induced cell death in glioma. ABSTRACT Glioma is the most common and lethal primary brain tumor in adults, with glioblastoma (GBM) representing the most aggressive subtype, characterized by diffuse infiltration, resistance to therapy, and a poor prognosis.
Farideh A. Javid, Andrej Belancic, Man Ki Kwok, Yun Wah Lam   +3 more
wiley   +1 more source

Multidisciplinary Management of Isocitrate Dehydrogenase-Mutated Gliomas in a Contemporary Molecularly Defined Era. [PDF]

J Clin Oncol
Kotecha R, Schiff D, Chakravarti A, Fleming JL, Brown PD, Puduvalli VK, Vogelbaum MA, Gondi V, Gallus M, Okada H, Mehta MP.   +10 more
europepmc   +1 more source