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Isocitrate dehydrogenase 1 gene mutations: a case review unveiling its biological impact on disease progression, prognosis and treatment in Chilean patients. [PDF]

BJR Case Rep
de Mayo Glasser T, García-Bloj B, Godoy JA, Sigler Chávez F, Retamal IN, Gómez-Valenzuela F, Silva I, Muñoz-Medel M, Sánchez C, Pinto F, Aravena P, Corvalán I, Erpel JM, Manque PA, Garrido M.   +14 more
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Predicting Isocitrate Dehydrogenase (IDH) Mutation Status in Gliomas Using Multiparameter MRI Radiomics Features

Journal of Magnetic Resonance Imaging, 2020
Accurate and noninvasive detection of isocitrate dehydrogenase (IDH, including IDH1 and IDH2) status is clinically meaningful for molecular stratification of glioma, but remains challenging.
Hong Peng, Jiaohua Huo, Bo Li, Yuanyuan Cui, Hao Zhang, Liang Zhang, Lin Ma   +6 more
semanticscholar   +1 more source

Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d‐2‐hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma

Histopathology, 2020
Dedifferentiated chondrosarcoma (DDCHS) is an aggressive type of chondrosarcoma that results from high‐grade transformation of a low‐grade chondrosarcoma. Mutations in the isocitrate dehydrogenase (IDH) 1 gene and the IDH2 gene that lead to increased d‐2‐
Nissreen Mohammad, D. Wong, A. Lum, Jonah Lin, Julie Ho, Cheng-Han Lee, S. Yip   +6 more
semanticscholar   +1 more source

Role of isocitrate dehydrogenase in glioma

Expert Review of Neurotherapeutics, 2011
Recently, the isocitrate dehydrogenase (IDH) enzymes have become a focal point for research aimed at understanding the biology of glioma and identifying novel targets for therapy. Following the publication of a landmark genetic sequencing study in 2008, which identified IDH1 as a frequently mutated gene in glioblastoma, much work has been carried out ...
Brian M, Alexander, Minesh P, Mehta
openaire   +2 more sources

Isocitrate dehydrogenase kinase/phosphatase

Biochimie, 1989
In Escherichia coli, isocitrate dehydrogenase (IDH) is regulated by phosphorylation. This phosphorylation cycle is catalyzed by an unusual, bifunctional protein:IDH kinase/phosphatase. IDH kinase/phosphatase is expressed from a single gene, aceK, and both activities are catalyzed by the same polypeptide.
D C, Laporte, C S, Stueland, T P, Ikeda
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The isocitrate dehydrogenase from cyanobacteria

Archives of Microbiology, 1983
The present communication describes the properties of isocitrate dehydrogenase in crude extracts from the unicellular Anacystis nidulans and from heterocysts and vegetative cells of Nostoc muscorum and Anabaena cylindrica. The activity levels of this enzyme are much higher in heterocysts than in vegetative cells of N. muscorum and A.
H, Papen, G, Neuer, M, Refaian, H, Bothe
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Isocitrate dehydrogenase of Tetrahymena pyriformis

Molecular and Cellular Biochemistry, 1977
We have studied the isocitrate dehydrogenase of Tetrahymena pyriformis. This enzyme is able to utilize both NAD and NADP, but kinetic studies suggest that the enzymatic activity with NAD is not of physiological signifance. Some of the factors that might regualte the NADP-dependent isocitrate dehydrogenase were also studied.
P, Vidal, A, Machado
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Serum isocitric dehydrogenase and glutamic dehydrogenase in schistosomiasis

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1969
Abstract 19 patients with schistosomiasis were studied for serum ICDH and GLDH activities; they were divided into two groups according to the presence or absence of hepatic involvement. Serum ICDH levels were normal, except in one patient with advanced hepatic decompensation.
Y, Mohran, K, Bsmi, M S, Shoeb, M R, Zawahiri, Y A, Ghaffer   +4 more
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