Results 321 to 330 of about 358,941 (349)
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Isocitric Lyase and Isocitric Dehydrogenase in Germinating Lettuce
Physiologia Plantarum, 1968AbstractA soluble isocitric lyase is shown to occur in lettuce seeds. Its activity increases during germination till 72 hours and then falls again. No particulate lyase could be detected. In addition both a soluble and a particulate isocitric dehydrogenase is present in the seeds. Both enzymes react with NAD as well as with NADP.
A. M. Mayer +2 more
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The estimation of d-isocitric acid in urine using isocitrate dehydrogenase
Clinica Chimica Acta, 1978The amount of D-isocitric acid in urine has been estimated using the enzyme isocitrate dehydrogenase. The technique is rapid and easy to perform. Reproducibility of results was good and results from recovery experiments were excellent. The concentration range for early morning urine samples from normal adults was 0.08-0.65 mmol/l with a mean of 0.29 ...
D J, Sutor, J M, Percival
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Mitochondrial Isocitrate Dehydrogenase and Isocitrate Oxidation of Rat Ventral Prostate
Enzyme, 1976Mitochondrial preparations isolated from rat ventral prostate were capable of oxidizing isocitrate by way of NADP isocitrate dehydrogenase (NADP-IDH) and NAD-IDH. NAD-IDH activity required ADP for activation. The pH responses for NAD-IDH and NADP-IDH were quite different.
L C, Costello, R, Franklin, R, Stacey
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Isocitrate dehydrogenase 1 mutations in melanoma frequently co‐occur with NRAS mutations
Histopathology, 2018Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme that converts isocitrate to α‐ketoglutarate. IDH1 mutations are associated with the accumulation of the oncometabolite D‐2‐hydroxyglutarate, which acts as an epigenetic modifier, and the development
K. Linos, L. Tafe
semanticscholar +1 more source
The inactivation of isocitrate dehydrogenase by a lipid peroxide
Archives of Biochemistry and Biophysics, 1971Abstract The isocitrate dehydrogenases of rat liver were found extremely sensitive to inacvation by linoleic acid hydroperoxide. Lipid peroxide was much more effective than other peroxides and sulfhydryl reagents tested. Dehydrogenase activity of crude subcellular fractions was more sensitive than the activity of the purified enzyme. The inactivation
R C, Green, C, Little, P J, O'Brien
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Development of Novel Therapeutics Targeting Isocitrate Dehydrogenase Mutations in Cancer.
Current Topics in Medicinal Chemistry, 2018Isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 regulate several cellular processes, including oxidative respiration, glutamine metabolism ...
H. Sharma
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An Evaluation of Isocitric Dehydrogenase in Liver Disease
Annals of Internal Medicine, 1961Excerpt Laboratory evaluation of hepatocellular damage has been aided in recent years by the development of new methods for measuring serum activities of enzymes released from injured liver cells.
N N, COHEN, H P, POTTER, G N, BOWERS
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Genetic polymorphism of Isocitrate dehydrogenase in Primates
Human Genetics, 1973The genetic polymorphism of isocitrate dehydrogenase has been investigated in 400 Primates. Six different phenotypes of the soluble enzyme were demonstrated. The mitochondrial enzyme exhibited a uniform electrophoretic pattern.
J, Schmitt, H, Ritter
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Crystallization of NADP-Specific Isocitrate Dehydrogenase
Science, 1973The first crystalline preparation of isocitrate dehydrogenase specific for nicotinamide adenine dinucleotide phosphate has been obtained with enzyme isolated from Escherichia coli . Scanning electron microscopy was employed to elucidate the structure of the crystals, which were found to exist as regular octahedrons ...
W F, Burke, J R, Swafford, H C, Reeves
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European Journal of Biochemistry, 1984
Isocitrate dehydrogenase kinase can use ATP but not other nucleoside triphosphates as a phosphate donor. It responds hyperbolically to both ATP and isocitrate dehydrogenase. The kinase is inhibited sigmoidally by low concentrations of DL‐isocitrate and hyperbolically by ADP, AMP, NADPH, phosphoenolpyruvate and several other effectors.
G A, Nimmo, H G, Nimmo
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Isocitrate dehydrogenase kinase can use ATP but not other nucleoside triphosphates as a phosphate donor. It responds hyperbolically to both ATP and isocitrate dehydrogenase. The kinase is inhibited sigmoidally by low concentrations of DL‐isocitrate and hyperbolically by ADP, AMP, NADPH, phosphoenolpyruvate and several other effectors.
G A, Nimmo, H G, Nimmo
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