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Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress [PDF]

open access: yesPLoS ONE, 2017
According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia.
Katharina Hohlbaum   +2 more
exaly   +4 more sources
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Prostate cancer cell malignancy via modulation of HIF-1α pathway with isoflurane and propofol alone and in combination

open access: yesBritish Journal of Cancer, 2014
Background:Surgery is considered to be the first line treatment for solid tumours. Recently, retrospective studies reported that general anaesthesia was associated with worse long-term cancer-free survival when compared with regional anaesthesia.
, Charlotte Bevan
exaly   +2 more sources

Isoflurane anesthesia is stereoselective

European Journal of Pharmacology, 1992
The anesthetic effects of the (+) and (-) isomers of isoflurane were determined in mice. Like the clinically important racemate, both isomers produced dose-dependent increases in anesthetic sleep time. A statistically significant (P less than 0.005, ANOVA) difference in the potencies of these isomers ((+) greater than (-)) was observed.
Eric J. Moody   +3 more
openaire   +3 more sources

Gallstones and isoflurane hepatitis

Anaesthesia, 1998
This report is of a case of a previously fit 65‐year‐old woman who developed postoperative liver dysfunction following an anaesthetic involving isoflurane. Biliary ultrasound demonstrated gallstones. However, serum antibodies to trifluoroacetylated proteins were detected, suggesting that immune sensitisation to the anaesthetic could have contributed to
D. J. Meldrum, R. Griffiths, J G Kenna
openaire   +3 more sources

Dexmedetomidine Reduces Isoflurane-Induced Neuroapoptosis Partly by Preserving PI3K/Akt Pathway in the Hippocampus of Neonatal Rats

open access: yesPLoS ONE, 2014
Prolonged exposure to volatile anesthetics, such as isoflurane and sevoflurane, causes neurodegeneration in the developing animal brains. Recent studies showed that dexmedetomidine, a selective α2-adrenergic agonist, reduced isoflurane-induced cognitive ...
Zhiyi Zuo
exaly   +2 more sources

Asthma and isoflurane

Pediatric Anesthesia, 1993
SummaryWe present a case report of a young child who had developed severe asthma by the age of 18 months and, in whom an acute exacerbation, required successful prolonged mechanical ventilation with isoflurane when conventional treatment had failed.
D.E. Griffiths, A.J. Matthews
openaire   +2 more sources

Impact of isoflurane on malignant capability of ovarian cancer in vitro

open access: yesBritish Journal of Anaesthesia, 2015
X. Luo   +7 more
exaly   +2 more sources

Emergence from isoflurane/N2O or isoflurane anaesthesia

Acta Anaesthesiologica Scandinavica, 1997
Background: The first goal of anaesthetic recovery is return of the patient's ability to independently maintain respiratory and circulatory functions. Nitrous oxide remains popular due to minor effects on the cardiovascular and respiratory systems. However, diffusion hypoxaemia can occur during recovery and there is a potential advantage of providing ...
Anders Bengtsson   +3 more
openaire   +3 more sources

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