Results 151 to 160 of about 801 (163)
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Isoginkgetin Inhibits RANKL-induced Osteoclastogenesis and Alleviates Bone Loss
Biochemical PharmacologyOsteoporosis is characterized by excessive osteoclast activity leading to bone loss, decreased bone mineral density, and increased susceptibility to fractures. Through in vivo/vitro experiments, along with network pharmacology analysis, we aimed to explore the underlying mechanisms of Isoginkgetin (IGG) in inhibiting osteoclastogenesis, providing ...
Zihe Wang +8 more
exaly +3 more sources
Optimization of a DNA‐launched SARS‐CoV‐2 replicon with RNA splicing inhibitor Isoginkgetin
Journal of Medical VirologyAbstractWe have previously developed a bacterial artificial chromosome (BAC)‐vectored SARS‐CoV‐2 replicon, namely BAC‐CoV2‐Rep, which, upon transfection into host cells, serves as a transcription template for SARS‐CoV‐2 replicon mRNA to initiate replicon replication and produce nanoluciferase (Nluc) reporter from the subgenomic viral mRNA.
Haitao Guo
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PhytomedicineNon-small cell lung cancer (NSCLC), which constitutes approximately 85% of all lung cancer cases, is a leading cause of cancer mortality worldwide. Isoginkgetin (ISO), a biflavonoid isolated from Ginkgo biloba leaves, has demonstrated anticancer effects against various malignancies. However, its anti-NSCLC effects are unclear.To explore the therapeutic
Chunyang, Zhu +8 more
exaly +3 more sources
Molecular Cancer Therapeutics, 2006
Abstract Matrix metalloproteinase (MMP)-9 plays a key role in tumor invasion. Inhibitors of MMP-9 were screened from Metasequoia glyptostroboides (Dawn redwood) and one potent inhibitor, isoginkgetin, a biflavonoid, was identified. Noncytotoxic levels of isoginkgetin decreased MMP-9 production profoundly, but up-regulated the level of ...
Yoon, SO Yoon, Sang-Oh +4 more
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Abstract Matrix metalloproteinase (MMP)-9 plays a key role in tumor invasion. Inhibitors of MMP-9 were screened from Metasequoia glyptostroboides (Dawn redwood) and one potent inhibitor, isoginkgetin, a biflavonoid, was identified. Noncytotoxic levels of isoginkgetin decreased MMP-9 production profoundly, but up-regulated the level of ...
Yoon, SO Yoon, Sang-Oh +4 more
openaire +3 more sources
Biochemical and Biophysical Research Communications
Ubiquitin-specific protease 8 (USP8) gene has been identified as being significantly amplified and overexpressed in Ovarian carcinoma (OC), and thus led to unfavorable clinical outcomes, implying that inhibition of USP8 may be a therapeutic strategy for OC. Herein, a structure-based discovery and bioassays were conducted to identify novel inhibitors of
Bingjin Hu +7 more
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Ubiquitin-specific protease 8 (USP8) gene has been identified as being significantly amplified and overexpressed in Ovarian carcinoma (OC), and thus led to unfavorable clinical outcomes, implying that inhibition of USP8 may be a therapeutic strategy for OC. Herein, a structure-based discovery and bioassays were conducted to identify novel inhibitors of
Bingjin Hu +7 more
openaire +2 more sources
Arteriosclerosis, Thrombosis, and Vascular Biology
Isoginkgetin (ISOGK) is a bioactive biflavonoid isolated from Ginkgo biloba , an eminent Chinese herbal medicine with hypolipidemic properties. This study was designed to investigate the therapeutic effects and mechanisms of action of ISOGK in treating hypercholesterolemia and atherosclerosis.
Zhidan Zhang +6 more
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Isoginkgetin (ISOGK) is a bioactive biflavonoid isolated from Ginkgo biloba , an eminent Chinese herbal medicine with hypolipidemic properties. This study was designed to investigate the therapeutic effects and mechanisms of action of ISOGK in treating hypercholesterolemia and atherosclerosis.
Zhidan Zhang +6 more
openaire +1 more source
Phytochemistry Letters
Flavonoids are the most extensively researched group of specialized plant metabolites that play a crucial role in various plant-environment interactions, with their biological activity greatly influenced by their molecular structure. They may occur as dimers, known as biflavonoids.
Šamec, Dunja, Jurčević Šangut, Iva
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Flavonoids are the most extensively researched group of specialized plant metabolites that play a crucial role in various plant-environment interactions, with their biological activity greatly influenced by their molecular structure. They may occur as dimers, known as biflavonoids.
Šamec, Dunja, Jurčević Šangut, Iva
openaire +1 more source
Toxicology and Applied Pharmacology
Sepsis-related acute lung injury (ALI) is a life-endangering respiratory disease. Isoginkgetin (IGK), a natural bioflavonoid, has antioxidant and immunoregulatory activities. This research examined the impacts of IGK on lipopolysaccharide (LPS)-stimulated ALI and investigated the underlying mechanisms.
Jian, Lu, Aiming, Li, Qiaoyan, Feng
exaly +3 more sources
Sepsis-related acute lung injury (ALI) is a life-endangering respiratory disease. Isoginkgetin (IGK), a natural bioflavonoid, has antioxidant and immunoregulatory activities. This research examined the impacts of IGK on lipopolysaccharide (LPS)-stimulated ALI and investigated the underlying mechanisms.
Jian, Lu, Aiming, Li, Qiaoyan, Feng
exaly +3 more sources