Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Risk Stratification Based on Endoscopic Ulcerative Findings in Patients with Endoscopic Non-Complete Response after Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer. [PDF]
Kido K +11 more
europepmc +1 more source
Catalytic Stereoselective Intermolecular Fluoroacylation of Unactivated Alkynes via C-F Bond Reconstruction. [PDF]
Kanji T +6 more
europepmc +1 more source
Platelet-related extracellular vesicles: Therapeutic roles in musculoskeletal disorders. [PDF]
Meng T, Wang Y, Tang X, Xiong J, Hu S.
europepmc +1 more source
Coexisting Moderate-to-Severe Tricuspid Regurgitation and Renal Dysfunction Identify a High-Risk Group After Transcatheter Aortic Valve Replacement. [PDF]
Lauten P +6 more
europepmc +1 more source
Association of Predicted Surgical Risk With 3-Year Outcomes After Isolated Tricuspid Valve Surgery: An Analysis of Medicare Beneficiaries. [PDF]
Mehaffey JH +6 more
europepmc +1 more source

