Results 191 to 200 of about 51,088 (234)

The theory of hypertensive heart disease and heart failure: revisiting the evidence and pathophysiology. [PDF]

J Hypertens
Bellicini MG.
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Pediatric Ambulatory Blood Pressure Patterns and Cardiovascular Risk. [PDF]

Curr Hypertens Rep
Sill J, Urbina E.
europepmc   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Hypertension Treatment with Angiotensin Receptor Blockers and Other Antihypertensive Agents: A Real-World Registry from a High-Volume Specialized Center Over TwoDecades. [PDF]

High Blood Press Cardiovasc Prev
Tocci G, Nardoianni G, Pala B, Russo M, Dutti GM, Giovanna G, Battistoni A, Barbato E, Volpe M.   +8 more
europepmc   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Highlights of the 2026 Korean Society of Hypertension guidelines for the management of hypertension: what's new and what has changed. [PDF]

Clin Hypertens
Lee EM, Cho IJ, Kang HT, Kim KI, Kim DH, Kim JH, Kim HL, Kim HC, Kim HJ, Koh ES, Park S, Park JM, Shin JH, Lee J, Lee HY, Lee H, Jung MH, Cho EJ, Choi S, Ihm SH, Committee of Korean Society of Hypertension Guidelines for the Management of Hypertension.   +20 more
europepmc   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Associations of triglyceride-glucose-body mass Index and C-reactive protein with isolated nocturnal hypertension: evidence from a retrospective observational study. [PDF]

Front Cardiovasc Med
Kaynak C.
europepmc   +1 more source

Limited Predictive Value of Inflammatory and Renal Markers in the Progression of Isolated Gestational Proteinuria to Preeclampsia: A Retrospective Cohort Study. [PDF]

J Clin Med
Sümer D, Filiz AA, Yıldırım P, Bayraktar A, Aslanlı İ, Göksu A, Çanga K, Vural Yılmaz Z.   +7 more
europepmc   +1 more source