Results 21 to 30 of about 42,511 (255)

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Inhibition of cholesterol synthesis and esterification regulates high density lipoprotein interaction with isolated epithelial cells of human small intestine

Journal of Lipid Research, 1990
The effect of two inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, lovastatin and monacolin L, and an inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), Sandoz compound 58-035, on the interaction of 125I-labeled high
DD Sviridov, MY Pavlov, IG Safonova, VS Repin, VN Smirnov   +4 more
doaj   +1 more source

Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins [PDF]

, 1998
Commonly, plant and invertebrate lectins are accepted glycohistochemical tools for the analysis of normal and altered structures of glycans in histology and pathology.
Bosbach, R., Brinck, U., Gabius, Hans-Joachim, Korabiowska, M.   +3 more
core   +1 more source

Changes of biochemical parameters in rat intestinal mucosa induced by methotrexate and effects of enteral administration of glutamine [PDF]

Archive of Oncology, 2004
BACKGROUND: Rapidly proliferating crypt cells of the intestinal epithelium, the precursors of the mature enterocytes, are extremely sensitive to the effects of cytostatic agents. We investigated the effects of the methotrexate on rat intestinal mucosa in
Bajin-Katić Katica, Stankov Karmen, Kovačević Zoran   +2 more
doaj   +1 more source

Suckling Piglet Intestinal Enterocyte Nutrient Metabolism Changes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Intestinal morphology and the types of enterocytes are changed in piglets during the suckling period, but it is unclear whether these changes are associated with metabolic changes in epithelium.
Qiye Wang, Xia Xiong, Xiaocheng Wang, Qiang Tu, Jianzhong Li, Xueqin Ding, Yali Li, Pengfei Huang, Shanping He, Yulong Yin, Huansheng Yang   +10 more
doaj   +1 more source

α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. [PDF]

, 2016
Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient ...
Atabai, Kamran, Azary, Saeedeh, Ha, Arnold, Hart, Daniel, Khalifeh-Soltani, Amin, McCarthy, Donald A, McKleroy, William, Podolsky, Michael J, Sakuma, Stephen, Stahl, Andreas, Tharp, Kevin M, Wu, Nanyan, Yokosaki, Yasuyuki   +12 more
core   +2 more sources

Influence of medication “Membranostabil” on expression of immunoreceptor proteins in small intestine of ruminants during the period of formation of colostral immunity

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2019
The influence of medication “Membranostabil” on the indexes of content of proteins with MM of 33, 40, and 47 kDa in the plasmolemma of enterocytes of jejunum of new-born calves during the period from birth till the age of 24-hours was investigated.
S. I. Holopura, M. I. Tsvilikhovsky, B. V. Popadiuk   +2 more
doaj   +1 more source

Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation. [PDF]

PLoS ONE, 2008
BACKGROUND: Intestinal ischemia-reperfusion (IR) is a phenomenon related to physiological conditions (e.g. exercise, stress) and to pathophysiological events (e.g. acute mesenteric ischemia, aortic surgery).
Joep P M Derikx, Robert A Matthijsen, Adriaan P de Bruïne, Annemarie A van Bijnen, Erik Heineman, Ronald M van Dam, Cornelis H C Dejong, Wim A Buurman   +7 more
doaj   +1 more source

Membrane lipid microenvironment modulates thermodynamic properties of the Na+-K+-ATPase in branchial and intestinal epithelia in euryhaline fish in vivo

Frontiers in Physiology, 2016
We have analyzed the effects of different native membrane lipid composition on the thermodynamic properties of the Na+-K+-ATPase in different epithelia from the gilthead seabream Sparus aurata. Thermodynamic parameters of activation for the Na+-K+-ATPase,
Mario Diaz, Rosa Dopido, Tomas Gomez, Covadonga Rodriguez   +3 more
doaj   +1 more source

Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins

Cells, 2022
Clostridioides bacteria are responsible for life threatening infections. Here, we show that in addition to actin, the binary toxins CDT, C2I, and Iota from Clostridioides difficile, botulinum, and perfrigens, respectively, ADP-ribosylate the actin ...
Carsten Schwan, Alexander E. Lang, Andreas Schlosser, Setsuko Fujita-Becker, Abdulatif AlHaj, Rasmus R. Schröder, Jan Faix, Klaus Aktories, Hans Georg Mannherz   +8 more
doaj   +1 more source