Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results From Retrospective Analysis [PDF]
Journal of Clinical Medicine, 2021 Isolated hypothyroxinemia (IH) unfavorably affects reproduction. This study aimed to evaluate retrospectively if any routinely measured clinical/laboratory parameters are associated with IH among women of childbearing age hospitalized in the endocrine department. A group of 466 female non-pregnant inpatients (age range 13–57 years) was considered.
Małgorzata Karbownik-Lewińska +2 more
exaly +5 more sources
Effect of maternal isolated hypothyroxinemia in the first trimester on offspring neurodevelopment: a prospective cohort study [PDF]
Frontiers in EndocrinologyObjectiveThis study aimed to examine the effect of maternal isolated hypothyroxinemia (IH) during early pregnancy on the neuropsychological development of the offspring.MethodsThis single-center prospective cohort study included 100 mother–child pairs ...
Jing Du +3 more
doaj +6 more sources
Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia [PDF]
Scientific Reports374 pregnant women with isolated hypothyroxinemia (IH) who were ≤ 20 weeks were included retrospectively in this study. Based on the confirmed gestational age and the use of levothyroxine (LT4), the patients were divided into the treated group (T1 group)
Dong Liu +11 more
doaj +4 more sources
Development of an animal model of hypothyroxinemia during pregnancy in Wistar rats [PDF]
Animal Models and Experimental MedicineBackground Hypothyroxinemia is a subclinical thyroid hormone deficiency in which the mother has inadequate levels of T4 during pregnancy. The fetus relies entirely on the mother's T4 hormone level for early neurodevelopment.
Wei Wei +7 more
doaj +3 more sources
Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study [PDF]
Reproductive Biology and EndocrinologyBackground The synergistic impact of isolate maternal hypothyroxinaemia (IMH) and other modulators on fetal growth outcomes is unknown. This study was aimed to determine whether third trimester IMH [free thyroxine level (FT4) below the the 5th percentile
Bin Zhang +5 more
doaj +4 more sources
The association of early pregnancy, particularly persistent isolated maternal hypothyroxinemia, with adverse obstetric and perinatal outcomes [PDF]
BMC Pregnancy and ChildbirthObjective We aimed to assess the association of early pregnancy isolated maternal hypothyroxinemia (IMH), including persistent IMH, with adverse obstetric and perinatal outcomes.
Mengfan Song, Mingtao Xiong, Yu Meng
doaj +4 more sources
Archives of Endocrinology and Metabolism, 2018 Objective: To evaluate the association of isolated hypothyroxinemia in the first trimester with obstetric and neonatal outcomes and iron deficiency. Subjects and methods: The study was prospective.
Pedro Weslley Rosario +2 more
doaj +2 more sources
Association of Isolated Hypothyroxinemia and Subclinical Hypothyroidism With Birthweight: A Cohort Study in Japan [PDF]
Journal of the Endocrine Society, 2023 AbstractContextIsolated hypothyroxinemia (low maternal free thyroxine [FT4] in the absence of thyroid-stimulating hormone [TSH] elevation) and subclinical hypothyroidism (high TSH in the absence of FT4 elevation) during early pregnancy are common.
Akiko Sankoda +8 more
openaire +3 more sources
Serum lipid profile in relation to free thyroxine and the effect of levothyroxine treatment on lipids in patients with isolated hypothyroxinemia during pregnancy: a single-center retrospective study [PDF]
Lipids in Health and Disease, 2022 Background Thyroid function is widely considered a lipid metabolism regulator. However, studies on lipid metabolism in pregnant women with low free thyroxine (FT4) levels are limited and inconclusive.
Yunyi Xu +4 more
doaj +2 more sources
Third-trimester estradiol is associated with isolated maternal hypothyroxinemia and attenuated TSH–FT4 coupling: evidence from rats and human astrocytes [PDF]
Frontiers in EndocrinologyIntroductionIsolated maternal hypothyroxinemia (IMH), defined by low free thyroxine (FT4) with thyroid-stimulating hormone (TSH) within the reference range, is a clinically relevant thyroid phenotype in late pregnancy, when estradiol (E2) rises sharply ...
Yajing Xu +4 more
doaj +2 more sources