Results 171 to 180 of about 4,752,749 (328)

In-depth comparison of methods to isolate RNA from common human cell lines. [PDF]

BMC Genomics
Zech TJ, Fürst R.
europepmc   +1 more source

Role ofmurFin Cell Wall Biosynthesis: Isolation and Characterization of amurFConditional Mutant ofStaphylococcus aureus

, 2006
Rita G. Sobral, Ana Madalena Ludovice, Hermı́nia de Lencastre, Alexander Tomasz   +3 more
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Autonomic regulation across sleep and wake during an Antarctic overwintering. [PDF]

Sci Rep
Tortello C, Folgueira A, Cauda B, González LE, Sala Lozano E, Pattyn N, Simonelli G, Plano SA, Vigo DE.   +8 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Lived Experiences of Social Isolation and Meaningful Relationships Among Older Adults Living with HIV with a Concurrent Mental Health Diagnosis: A Heideggerian Phenomenological Approach. [PDF]

Healthcare (Basel)
Kokorelias KM, Valentine D, Eaton AD, Munce SEP, Sheppard CL, Hitzig SL, Wasilewski MB, Zhabokritsky A, Abdelhalim R, Jamieson L, Harris MT, Sirisegaram L.   +11 more
europepmc   +1 more source

Robust Fault Detection, Isolation, and Accommodation of Current Sensors in Grid Side Converters

, 2016
Panayiotis Papadopoulos, Lenos Hadjidemetriou, Elias Kyriakides, Marios M. Polycarpou   +3 more
openalex   +2 more sources

Isolation and Analysis of the Lipid A Backbone [PDF]

, 1976
Sumihiro Hase, Ernst Rietschel
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Social Isolation and Sedentary Behavior: A Syndemic Driving the Metabolic Crisis in the United States. [PDF]

Public Health Rep
Melby GD, Fullilove R.
europepmc   +1 more source