Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives
American Journal of Hematology, EarlyView.ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
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Antibacterial Siderophores of Pandoraea Pathogens and Their Impact on the Diseased Lung Microbiota
Angewandte Chemie, EarlyView.Genome mining of environmental and pathogenic Pandoraea species identified a conserved NRPS gene cluster and led to the discovery of novel siderophores, pandorabactins, which exert their antibacterial activity by depleting iron from competitors. Bioinformatic analysis of sputum from cystic fibrosis patients coupled with bioassays indicates that ...
Elena Herzog +8 more
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Clonal Hematopoiesis and Thrombosis
American Journal of Hematology, EarlyView.ABSTRACT Clonal hematopoiesis (CH) has been the focus of many research efforts in the last years and has emerged as a risk modifier for cardiovascular disease morbidity and mortality. While substantial evidence has accumulated regarding its impact on arterial system diseases, the connection with venous thrombosis has only recently been explored.
Cornelia Englisch, Cihan Ay
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Isolation of Mycoplasma hominis in critically ill patients with pulmonary infections: clinical and microbiological analysis in an intensive care unit [PDF]
, 2006 Celia García +6 more
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1400Clinical and Microbiological Analysis of Staphylococcus lugdunensis isolates at UCLA [PDF]
Open Forum Infectious Diseases, 2014 Jennifer A. Veltman +6 more
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Annals of Neurology, EarlyView.At low levels of B12, specifically when bound to transcobalamin for cellular uptake, evidence of slower conductivity in the brain could point toward impaired myelin. At high levels of B12, specifically when bound to the biologically inert transport protein haptocorrin, biomarkers of neurodegeneration appear in the serum, indicating neuroaxonal injury ...
Alexandra Beaudry‐Richard +22 more
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PCR Detection and Microbiological Isolation of Salmonella spp. from Fresh Beef and Cantaloupes [PDF]
, 2008 Miguel Ángel Gallegos Robles +6 more
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Assessment of serology and spirometry and the combination of both to complement microbiological isolation for earlier detection of Pseudomonas aeruginosa infection in children with cystic fibrosis [PDF]
, 2016 Ana Kotnik Pirš +3 more
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Infection and Drug Resistance, 2018 Xiaodan Jiang,1,2,* Aihua Deng,3,* Jiarui Yang,1,2,* Hua Bai,3 Zhao Yang,3 Jie Wu,3 Huibin Lv,1,2 Xuemin Li,1,2 Tingyi Wen3,4 1Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China; 2Beijing Key Laboratory of Restoration of
Jiang X +8 more
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