Lienhwalides: Unique Tropolone–Maleidride Hybrids from Hypoxylon lienhwacheense
Lienhwalides are novel tropolone–maleidride hybrid molecules unique in nature. Absolute configuration is solved by semisynthetic approaches and X‐ray analysis. Interplay between both lwt and lwm biosynthetic gene clusters is responsible for the production of lienhwalides.
Katharina Schmidt+13 more
wiley +1 more source
Isolation and Epidemiology of Respiratory Bacteria From Unusual Sites: Demographic, Seasonal, and Geographic Distribution in a Laboratory-Based Study From a Tertiary Care Hospital in Karachi, Pakistan. [PDF]
Zehra SR+4 more
europepmc +1 more source
Pioneering Women Shaping the Field of Biocatalysis
Groundbreaking works of women scientists in biocatalysis are highlighted in this article. Their innovative contributions are categorized in four interrelated research areas, collectively driving advancements in enzymatic biotransformations. Abstract In this perspective article, we celebrate the accomplishments of female‐led research groups in ...
Ana I. Benítez‐Mateos+3 more
wiley +1 more source
Citizen Science to Raise Antimicrobial Resistance Awareness in the Community: The MicroMundo Project in Spain and Portugal. [PDF]
Gil-Serna J+41 more
europepmc +1 more source
Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation
A thioether‐mediated sulfenylation method based on 4‐fluorophenyl 3‐nitro‐2‐pyridinesulfenate (Npys‐OPh(pF)) is developed for Trp‐selective chemical modification. This sulfenylation proceeds under mild, metal‐free, and weakly acidic conditions and is broadly applicable to the chemical modification of various Trp‐containing peptides as well as the late ...
Hayate Shida+11 more
wiley +1 more source
Persistence in time: the hunt for <i>Bacillus anthracis</i> at a historic tannery site in Austria reveals genetic diversity thought extinct. [PDF]
Mayerhofer-Rochel MF+8 more
europepmc +1 more source
Structurally‐modified aminoglycosides, such as kanamycin, have shown promise as antibiotics and premature termination codon read‐through drugs to fight against drug‐resistant bacteria and to treat genetic diseases, respectively. Therefore, research on developing and discovering aminoglycoside antibiotics has recently increased.
Kanae Hosomi+7 more
wiley +1 more source
Genome sequence of a Tetraparvovirus ungulate 1 strain from a cow in Tennessee, USA. [PDF]
Elsakhawy OK+2 more
europepmc +1 more source
In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes
The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer+7 more
wiley +1 more source