Results 51 to 60 of about 13,913 (265)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Theoretical modeling and vibration analysis of cylindrical shell carrying internal machine and metamaterial isolator with broadband bandgaps

Advances in Mechanical Engineering
The vibration control of the cylindrical shell carrying internal machine and isolator is of significant interest to underwater vehicles. The metamaterial isolator that combines Bragg bandgap and local resonant bandgap, namely periodic isolator with ...
Yujun Liu, Yinping Cao, Jing Liu, Guang Pan   +3 more
doaj   +1 more source

Numerical investigation on shock train characteristics in cylindrical isolator via SATES method

Hangkong gongcheng jinzhan
In scramjet，the isolator plays a crucial role as a transitional component between the combustor and the inlet. Within the isolator，complex flow phenomena such as shock wave/boundary layer interactions，flow separation，and shock trains are observed under ...
XIE Pengfei, LIU Yifan, HAN Xingsi
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Fluid–Structure Interactions between Oblique Shock Trains and Thin-Walled Structures in Isolators

Aerospace
Understanding aeroelastic issues related to isolators is pivotal for the structural design and flow control of scramjets. However, research on fluid–structure interactions (FSIs) between thin-walled structures and the isolator flow remains limited.
Xianzong Meng, Ruoshuai Zhao, Qiaochu Wang, Zebin Zhang, Junlei Wang   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Modeling of the Dynamic Characteristics for a High-Load Magnetorheological Fluid-Elastomer Isolator

Actuators
To meet the vibration isolation requirements of engines under diverse operating conditions, this paper proposes a novel magnetorheological fluid-elastomer isolator with high load and tunable parameters.
Yu Tao, Wenhao Chen, Feifei Liu, Ruijie Han   +3 more
doaj   +1 more source

STUDI KOMPARASI BASE SHEAR PADA GEDUNG MENGGUNAKAN BASE ISOLATOR DAN NON BASE ISOLATOR

Teras Jurnal: Jurnal Teknik Sipil, 2017
Perencanaan struktur gedung di Indonesia masih minim dalam penggunaan base isolator pada wilayah gempa kuat seperti Aceh. Penelitian ini mengkombinasikan antara base isolator dan Sistem Rangka Pemikul Momen Khusus (SRPMK) sebagai sistem penahan gaya ...
ahmad ridho siagian, Wesli Wesli, Yovi Chandra, Said Jalalul Akbar   +3 more
doaj   +1 more source