Results 81 to 90 of about 13,913 (265)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Vibration isolation using a bar and an Euler beam as negative stiffness for vehicle seat comfort
Advances in Mechanical Engineering, 2019 In this article, the behavior and the efficiency of a nonlinear passive vibration isolator based on a bar and an Euler beam are investigated analytically.
Akintoye Olumide Oyelade
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
工程科学与技术, 2018 An innovative high-performance low-cost isolator was presented for seismic isolation in economic underdeveloped regions. When this proposed isolator is applied to replace steel sheets with engineering plastic plates within a traditional isolator, the ...
Ping TAN +3 more
doaj
Computational Investigations and Control of Shock Interference
Applied SciencesComputational fluid dynamics (CFD) has aided the development, design, and analysis of hypersonic airbreathing propulsion technologies, such as scramjets. The complex flow field in a scramjet isolator has been the subject of intense interest and study for
Cameron Alexander, Ragini Acharya
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Dissipation of Hysteretic Energy in Base Isolated Structure
Shock and Vibration, 1996 Dissipation of hysteretic energy in the isolator of the base isolated structure under seismic excitation is investigated. The hysteretic force-deformation characteristics of the base isolator is specified by a nonlinear differential equation.
R.S. Jangid, T.K. Datta
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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