Results 241 to 250 of about 196,977 (320)

Convergent Evolution and De Novo Reconstitution of Apiin Biosynthesis

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2562-2575, April 2026.
ABSTRACT Apiin, an active flavonoid apioside, occurs in phylogenetically distant plants, such as parsley and chilli pepper (Capsicum annuum L.). Its sporadic distribution suggests the existence of convergent apiin biosynthesis; however, the molecular mechanisms underlying this convergence remain unclear.
Zhen Xu, Zheng‐Shuang Zhu, Hai‐Zhu Jia, Jian‐Qiang Kong   +3 more
wiley   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

Endocrine disrupting chemicals and the adrenal gland. [PDF]

Turk J Med Sci
Şimşek Bağir G, Ertörer ME.
europepmc   +1 more source

PROTEIN DISULFIDE ISOMERASE LIKE 5-1 is a susceptibility factor to plant viruses

Proceedings of the National Academy of Sciences of the United States of America, 2014
Ping Yang, Thomas Lüpken, A. Habekuss, G. Hensel, B. Steuernagel, B. Kilian, R. Ariyadasa, A. Himmelbach, J. Kumlehn, U. Scholz, F. Ordon, N. Stein   +11 more
semanticscholar   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Familial Dystonia Due to Homozygous TPI1 c.718G>A (p.Glu240Lys): A Three-Sibling Case Series Including Two Treated with Deep Brain Stimulation of the Globus Pallidus Internus. [PDF]

Ann Indian Acad Neurol
Yavuz Z, Önder H, Munis ÖB, Çomoğlu SS.   +3 more
europepmc   +1 more source

Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food‐derived lactobacilli

Journal of Applied Microbiology, 2014
B. Yang, H. Chen, Zheng Gu, F. Tian, R. Ross, C. Stanton, Y. Chen, W. Chen, H. Zhang   +8 more
semanticscholar   +1 more source

Methionine Salvage Enzyme Uses a Unique Mechanism to Overcome a Challenging Aldose-Ketose Isomerization. [PDF]

J Am Chem Soc
Ubayawardhana ST, Das T, Corio SA, Hirschi JS, Murkin AS.   +4 more
europepmc   +1 more source

Multi-layered metabolic remodeling of <i>Pseudomonas putida</i> for efficient conversion of lignocellulosic sugars to the precursors of advanced aviation fuel. [PDF]

Metab Eng Commun
Kang CW, Carruthers DN, McCauley J, Chen Y, Gin JW, Petzold CJ, Simmons BA, Lee TS.   +7 more
europepmc   +1 more source

Identification and Experimental Validation of Triosephosphate Isomerase 1 as a Functional Biomarker of SHetA2 Sensitivity in Ovarian Cancer. [PDF]

Cells
Mortan LF, Isingizwe ZR, Benbrook DM.
europepmc   +1 more source