Results 241 to 250 of about 90,505 (292)

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu   +4 more
wiley   +1 more source

Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song   +3 more
wiley   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao   +3 more
wiley   +1 more source

Streamline Protocol for Arabidopsis Apoplastic Fluid Isolation Enables a Detailed Proteomic View of the Plant Extracellular Space

open access: yesPlant Direct, Volume 9, Issue 7, July 2025.
ABSTRACT The apoplastic space surrounding plant cells, encompassing the cell wall matrix, extracellular spaces, and xylem, is one of the least understood compartments within plant tissues due to its lack of limiting membranes and its unavoidable damage upon tissue homogenization. Using a streamlined vacuum‐infiltration/centrifugation protocol to enrich
Kuo‐En Chen   +2 more
wiley   +1 more source

The structure of a family 168 glycoside hydrolase from the marine bacterium Muricauda eckloniae

open access: yesActa Crystallographica Section F, Volume 81, Issue 7, Page 281-286, July 2025.
The structure of a putative fucoidan‐degrading glycoside hydrolase assigned to glycoside hydrolase family 168 reveals a (β/α)8 fold. The catalytic machinery and potential substrate specificity were investigated through a structural comparison with a Fun168A oligosaccharide complex.The genome of the marine bacterium Muricauda eckloniae sp.
Emily Knudson-Goerner   +1 more
wiley   +1 more source

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