Results 141 to 150 of about 28,431 (272)

A fetus with meckel-gruber syndrome associated with isomerism

Open Medicine, 2014
Kitova Tanya, Kilova Kristina, Kitov Borislav, Masmoudi Aida, Milkov Denis, Gaigi Soumeya   +5 more
doaj   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +2 more sources

High Spin Iron–Phosphinidene and Arsinidene Complexes With Attenuated Metal–Ligand Multiple Bond Character

Angewandte Chemie, EarlyView.
Unusually low metal–ligand bond orders are observed in high spin iron(II) pnictogenidene (PH2– and AsH2–) complexes. Electronic structure analysis provides evidence for multiconfigurational character that attenuates the metal–ligand multiple bond character normally that is typically associated with pnictogenidene ligands. These complexes can be used to
Austin D. Chivington, Álvaro García‐Romero, David C. Meier, Maren Pink, Jose M. Goicoechea, Jeremy M. Smith   +5 more
wiley   +2 more sources

Donor–Acceptor Pentacene Analogues With Near‐Infrared Emission and Tunable Aromaticity

Angewandte Chemie, EarlyView.
Air‐ and photostable heterocyclic pentacene analogues with donor and acceptor groups flanking a para‐quinodimethane core exhibit large dipole moments, narrow bandgaps, reversible redox behavior, and NIR‐I to NIR‐II absorption and emission with pronounced solvatochromism.
Krzysztof Nowak, Olaf Morawski, Muhammad Yasir Mehboob, Maja Morawiak, Krzysztof Noworyta, Cina Foroutan‐Nejad, Marek Grzybowski   +6 more
wiley   +2 more sources

Steering the Shape‐shifting of Bullvalene‐PdII Complexes Through Steric and Geometric Strain

Angewandte Chemie, EarlyView.
This study explores the use of bis‐pyridyl substituted bullvalenes as dynamic shape‐shifting ligands within cis‐capped PdII complexes. The ring position of the pyridyl nitrogen is critical, leading to a range of Pd2L2 metallacycles and simple PdL complexes, each with distinctive bullvalene isomer preferences (represented in the figure by A‐D isomer ...
André P. Birvé, Witold M. Bloch, Thomas Fallon   +2 more
wiley   +2 more sources

Cardiac conduction system malformations in heterotaxy result from dysregulated Pitx2 expression. [PDF]

JCI Insight
Joo K, Matsuoka R, Kitajima K, Yashiro K, Shiose A, Tominaga R, Shen MM, Oki S, Meno C.   +8 more
europepmc   +1 more source

Small‐Molecule Activation of mRNA Translation by Click‐to‐Release Reaction in Cells

Angewandte Chemie, EarlyView.
A new method to control mRNA activity using bioorthogonal click‐to‐release reactions is presented. The 5′ cap is modified with a trans‐cyclooctene (TCO) that quickly reacts with hydroxyaryl‐tetrazines and efficiently releases the native cap 0. TCO‐capped mRNAs are initially translationally inactive but can be activated with non‐toxic, cell‐permeable ...
Tess Vosman, Friedrich Burba, Martin Sumser, Milan Vrabel, Hannes Mikula, Andrea Rentmeister   +5 more
wiley   +2 more sources

Ivemark syndrome in an adult with complete atrioventricular septal defect and a single ventricle with L-transposition of the great arteries: a case report. [PDF]

J Med Case Rep
Hibatouallah H, El-Mhadi S, Siagh S, Touati Z, Cherti M.   +4 more
europepmc   +1 more source

Prenatal Diagnosis of Joubert Syndrome 23 With Left Isomerism: A Novel Phenotype Associated With Pathogenic KIAA0586 Variant. [PDF]

Prenat Diagn
Casteleyn T, Vogt M, Weichert A, Zimmer B, Lala B, Henrich W, Königbauer JT.   +6 more
europepmc   +1 more source

Predicting and Rationalizing Piezoelectricity in Racemic Bioorganic Molecular Crystals

Angewandte Chemie, EarlyView.
Racemic molecular crystals, composed of equal mixtures of chiral enantiomeric components, are predicted to exhibit significant piezoelectric responses and favourable mechanical flexibility. This study identifies organic and bioorganic racemates as promising candidates for sustainable, lead‐free materials, enabling next‐generation applications in energy
Shubham Vishnoi, Sarah Guerin
wiley   +2 more sources