Results 101 to 110 of about 89,475 (303)

Ranolazine Attenuates Trastuzumab-Induced Heart Dysfunction by Modulating ROS Production [PDF]

, 2018
The ErbB2 blocker trastuzumab improves survival in oncologic patients, but can cause cardiotoxicity. The late Na+ current inhibitor ranolazine has been shown to counter experimental HF, including doxorubicin cardiotoxicity (a condition characterized by ...
Carlo G. Tocchetti, Carlo Maurea, Carmela Coppola, Chiara D'Avino, Chiara D'Avino, Claudia De Lorenzo, Claudia De Lorenzo, Claudio Arra, Danilo Fiore, Domenica Rea, Fabio Di Lisa, Gennaro Riccio, Gerolama Condorelli, Giovanna Piscopo, Michele Russo, Nicola Maurea, Salvatore Antonucci   +16 more
core   +3 more sources

A Novel Approach for Localizing Non‐Sustained Atrial Arrhythmias: Atrial Pace‐Mapping With Automatic Intracardiac Pattern Matching

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Ventricular pace mapping is an established tool to identify the origin of non‐inducible arrhythmias by analyzing the paced QRS morphology of the surface electrocardiogram (ECG). Using the same approach for atrial pace mapping (APM) was shown to be suboptimal, as accurate assessment of P wave morphology can be limited. We present a
Evgeny Lian, Vera Maslova, Sven Willert, Adrian Zaman, Derk Frank, Fabian Moser   +5 more
wiley   +1 more source

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79 [PDF]

, 2001
The beta 2 adrenergic receptor (beta 2AR) undergoes desensitization by a process involving its phosphorylation by both protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs). The protein kinase A-anchoring protein AKAP79 influences beta 2AR
Chen, Wei, Cong, Mei, Fraser, Iain D., Hu, Liaoyuan A., Lefkowitz, Robert J., Lin, Fang-Tsyr, Perry, Stepehn J., Pitcher, Julie A., Scott, John D.   +8 more
core  

Fascicular/Purkinje Tissue Colocalized With Scar in Cardiomyopathy Patients Undergoing Ventricular Fibrillation Ablation

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Ventricular fibrillation (VF) is a poorly understood arrhythmia that is one of the main mechanisms of sudden cardiac death in patients with structural heart disease (SHD). Fascicular and Purkinje tissue (FPT) has been implicated in VF.
Emir Baskovski, Timucin Altin, Omer Akyurek, Turkan Seda Tan, Mahmut EkremCunetoglu, Irem Muge Akbulut, Volkan Kozluca, Nail Burak Ozbeyaz, Eralp Tutar   +8 more
wiley   +1 more source

p75 neurotrophin receptor regulates energy balance in obesity [PDF]

, 2016
Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD).
Akassoglou, Katerina, Baeza-Raja, Bernat, Baillie, George S., Chan, Justin P., Christian, Frank, Davalos, Dimitrios, Houslay, Miles D., Le Moan, Natacha, Li, Pingping, Olefsky, Jerrold M., Ryu, Jae Kyu, Sachs, Benjamin D., Saltiel, Alan R., Scadeng, Miriam, Sikorski, Shoana L., Taylor, Susan S., Vagena, Eirini   +16 more
core   +3 more sources

Isoproterenol-lnduced Diuresis in Turkeys

Experimental Biology and Medicine, 1977
SummaryThe isoproterenol-induced diuresis in turkeys is associated with an increase in CCr and CH2O. The effect is probably mediated, in part, by β-adrenergic receptors in the afferent arteriole which lead either to recruitment of reptilian-type nephrons or more filtration by individual neph-rons.
Melvin J. Fregly, Charles F. Simpson, W. P. Palmore   +2 more
openaire   +3 more sources

The heart, a secondary organ in the control of blood circulation

Experimental Physiology, Volume 110, Issue 5, Page 649-665, 1 May 2025.
Abstract Circulation of the blood is a fundamental physiological function traditionally ascribed to the pressure‐generating function of the heart. However, over the past century the ‘cardiocentric’ view has been challenged by August Krogh, Ernst Starling, Arthur Guyton and others, based on haemodynamic data obtained from isolated heart preparations and
Branko Furst, José González‐Alonso
wiley   +1 more source

Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro *

Journal of Biological Chemistry, 1998
Hormone-sensitive lipase (HSL) is the rate-limiting enzyme in lipolysis. Stimulation of rat adipocytes with isoproterenol results in phosphorylation of HSL and a 50-fold increase in the rate of lipolysis.
M. Anthonsen, L. Rönnstrand, C. Wernstedt, E. Degerman, C. Holm   +4 more
semanticscholar   +1 more source

A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes [PDF]

, 1995
In many tissues, inwardly rectifying K channels are coupled to seven- helix receptors via the Gi/Go family of heterotrimeric G proteins. This activation proceeds at least partially via G beta gamma subunits.
Dascal, Nathan, Davidson, Norman, Labarca, Cesar, Lester, Henry A., Lim, Nancy Fidler   +4 more
core   +2 more sources

Sex‐specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)

The Journal of Physiology, EarlyView.
Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus, Praveen Kumar, Kelly Kneale, T. Noah Hutson, Nicole M. Gautier‐Hall, Deng‐Shan Shiau, Megan Watts, Krystle Trosclair, Hemangini A. Dhaibar, Paari Dominic, Leonidas Iasemidis, Edward Glasscock   +11 more
wiley   +1 more source