Results 111 to 120 of about 56,118 (235)

Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC) and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying this phenotype are unclear.
Paige C. Arneson‐Wissink, Katherine Pelz, Beth Worley, Heike Mendez, Peter Pham, Parham Diba, Peter R. Levasseur, Grace McCarthy, Alex Chitsazan, Jonathan R. Brody, Aaron J. Grossberg   +10 more
wiley   +1 more source

Bilateral Cardiac Sympathetic Denervation in Inherited Cardiac Arrhythmias

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
The figure shows the outcomes and adverse effects experienced by five patients who underwent BCSD for inherited arrhythmias, including CPVT and LQTS. BCSD resulted in significant or partial effects and favorable outcomes. Case 1: In a patient with CPVT, polymorphic ventricular tachycardia was not induced after BCSD.
Hisaaki Aoki, Michiko Minegishi, Katsunori Okajima, Takashi Kumamoto, Daiji Takeuchi   +4 more
wiley   +1 more source

The role of CaMKII-dependent augmented INa,L in arrhythmias during acute β-adrenergic stimulation [PDF]

, 2018
The heart has evolved elaborate pathways for adapting function to acute stress stimuli [e.g. sympathetic stimulation of β-adrenergic receptors (β-ARs)].
Lane, Cemantha
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The Evolving Role of Ivabradine for Focal Atrial Tachycardia: A Systematic Review

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Overview of the evolving role of ivabradine in focal atrial tachycardia (FAT), highlighting its HCN‐mediated mechanism, features of ivabradine‐sensitive FAT, hypothesized predictors of response, special populations requiring special considerations, and potential adverse effects.
Haikal Balweel, Rifqi Rizkani Eri, Sania Zahrani, Kiara Hanna Quinncilla, Novaro Adeneur Tafriend, Agus Harsoyo   +5 more
wiley   +1 more source

Biofilm‐Antagonist Ginger‐Based 3D‐Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications

Advanced Materials, Volume 38, Issue 15, 12 March 2026.
This work offers unique Ginger‐based 3D‐printable resins that can print customizable high‐resolution complex designs. The customizable printing backbone of Zingerol prints also mimics various human bones' strength. Acquisition of in‐vivo biocompatibility in rat model with no severe inflammatory response, along with in‐vitro antioxidant and ex‐vivo anti‐
Simran Jindal, Majd Bisharat, Bassma Khamaisi, Krishanu Ghosal, Eid Nassar‐Marjiya, Qi Wu, Shadi Daoud, Idan Redenski, Samer Srouji, Shady Farah   +9 more
wiley   +1 more source

Effects of Intrauterine Isoproterenol Administration on Ovarian Follicular Development in Cows

Veterinary Medicine and Science
Background Isoproterenol (ISO) is a nonselective beta‐adrenergic receptor agonist known for its vasodilatory effects. This experiment aims to investigate whether intrauterine ISO administration could alter vascular indices and follicular development in ...
Vefa Tohumcu, Mehmet Cengiz, A. Hayirli, K. Altinkaynak, Emre Arslanbas, Alper Yasin Ciplak, S. Aydın, Omercan Alat   +7 more
doaj   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

From Redox Imbalance to Tissue Injury: Insights Into Antidepressant Drug Amitriptyline Effects on Salivary Glands

Cell Biochemistry and Function, Volume 44, Issue 3, March 2026.
ABSTRACT This study aimed to investigate the effects of amitriptyline administration on the salivary glands and saliva of rats. Twenty‐eight male Wistar rats (60 days old) were divided into two groups (n = 14 per group): control and amitriptyline‐treated (10 mg/kg/day for 30 days).
Cristian dos Santos Pereira, Deiweson Souza‐Monteiro, Yago Gecy de Sousa Né, Jorddy Neves da Cruz, Vinicius Ruan Neves dos Santos, Everton Luiz Pompeu Varela, Sandro Percário, Leonardo Oliveira Bittencourt, Antonio Hernandes Chaves‐Neto, Rafael Rodrigues Lima   +9 more
wiley   +1 more source

Maintenance of Carnitine Homeostasis as a Therapeutic Strategy to Attenuate Cisplatin‐Induced Acute Kidney Injury

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an Wu   +5 more
wiley   +1 more source

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79 [PDF]

, 2001
The beta 2 adrenergic receptor (beta 2AR) undergoes desensitization by a process involving its phosphorylation by both protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs). The protein kinase A-anchoring protein AKAP79 influences beta 2AR
Chen, Wei, Cong, Mei, Fraser, Iain D., Hu, Liaoyuan A., Lefkowitz, Robert J., Lin, Fang-Tsyr, Perry, Stepehn J., Pitcher, Julie A., Scott, John D.   +8 more
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