Results 111 to 120 of about 56,897 (225)

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Kawasaki Disease Shock Syndrome With Progressive AV Block and Atrioventricular Dissociation: Case Report

Journal of Paediatrics and Child Health, EarlyView.
Chengjun Dai, Jiao Chen, Yutong Chen, Yingchao Ying, Yanlan Fang, Zihao Yang, Chunlin Wang   +6 more
wiley   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages [PDF]

, 2019
学位記番号 ...
Bu, Yun, ブ, イュン, 歩, 云
core  

Ablation of Atrial Tachycardia in a Budd‐Chiari Syndrome Patient via Inferior Vena Cava–Azygos–Superior Vena Cava Approach

Annals of Noninvasive Electrocardiology, Volume 31, Issue 1, January 2026.
ABSTRACT Introduction Catheter ablation for atrial tachycardia (AT) in Budd‐Chiari syndrome (BCS) presents unique challenges due to altered venous anatomy. This case demonstrates an innovative approach to overcome complete inferior vena cava (IVC) occlusion.
Yuwei Chen, Yi Liu, Xiangbin Xiao, Xiaobo Pu   +3 more
wiley   +1 more source

Hydrostatic Pressures in Lymphatic Networks of the Mouse

Microcirculation, Volume 33, Issue 1, January 2026.
ABSTRACT Objective Current research on the lymphatic system makes nearly exclusive use of mouse models because that species is highly amenable to genetic manipulation. However, the lack of information about intraluminal hydrostatic pressures in mouse lymphatic networks limits the ability of investigators, for both in vivo and ex vivo studies, to ...
Michael J. Davis
wiley   +1 more source

Differentiating Left Atrial Pressure Responses in Paroxysmal and Persistent Atrial Fibrillation: Implications for Diagnosing Heart Failure With Preserved Ejection Fraction and Managing Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Increased left atrial pressure (LAP) contributes to dyspnea and heart failure with preserved ejection fraction in patients with atrial fibrillation (AF).
Jong Sung Park, Iksung Cho, Daehoon Kim, Moon‐Hyun Kim, Je‐Wook Park, Hee Tae Yu, Tae‐Hoon Kim, Jae‐Sun Uhm, Boyoung Joung, Moon‐Hyoung Lee, Hui‐Nam Pak   +10 more
doaj   +1 more source

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79 [PDF]

, 2001
The beta 2 adrenergic receptor (beta 2AR) undergoes desensitization by a process involving its phosphorylation by both protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs). The protein kinase A-anchoring protein AKAP79 influences beta 2AR
Chen, Wei, Cong, Mei, Fraser, Iain D., Hu, Liaoyuan A., Lefkowitz, Robert J., Lin, Fang-Tsyr, Perry, Stepehn J., Pitcher, Julie A., Scott, John D.   +8 more
core  

Osborn Waves: History and Significance [PDF]

, 2004
The Osborn wave is a deflection with a dome or hump configuration occurring at the R-ST junction (J point) on the ECG (Fig. 1). In the historical view, different names have been used for this wave in the medical literature, such as “camel-hump sign ...
Atarashi, Hirotsugu, Hirayama, Yoshiyuki, Katoh, Takao, Kobayashi, Yoshinori, Kodani, Eitaroh, Maruyama, Mitsunori, Takano, Teruo   +6 more
core   +2 more sources

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans [PDF]

, 2018
Finck, Brian N., Franczyk, Michael, H. Liss, Kim H., Hall, Angela M., Klein, Samuel, Lutkewitte, Andrew J., Pietka, Terri, Yoshino, Jun   +7 more
core   +2 more sources