Results 131 to 140 of about 56,118 (235)

Cardiac‐specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility

Experimental Physiology, Volume 111, Issue 3, Page 1120-1133, 1 March 2026.
Abstract The leading cause of epilepsy‐related mortality is sudden unexpected death in epilepsy (SUDEP), resulting from seizure‐induced cardiorespiratory arrest by mechanisms that remain unresolved. Mutations in ion channel genes expressed in both brain and heart represent SUDEP risk factors because they can disrupt neural and cardiac rhythms ...
Kelsey Halvorson, Man Si, Krystle Trosclair, Ellen Aughenbaugh, Maxine Parkinson, Nicole M. Gautier‐Hall, Megan Watts, Frederica Kizek, Md. Shenuarin Bhuiyan, Paari Dominic, Kathryn A. Hamilton, Edward Glasscock   +11 more
wiley   +1 more source

A model of β‐adrenergic stimulation in human ventricular cells for tissue‐scale simulations of sympathetically modulated tachycardias

The Journal of Physiology, Volume 604, Issue 5, Page 1897-1914, 1 March 2026.
Abstract figure legend Modelling β‐adrenergic stimulation in sympathetically remodelled ventricular substrates. Myocardial infarction could result in sympathetic remodelling in ventricular tissues, which affects arrhythmia dynamics. However sympathetic remodelling is challenging to control experimentally; therefore we created an ionic model that ...
Kelly Zhang, Karl Magtibay, Natalia Trayanova, Edward Vigmond   +3 more
wiley   +1 more source

Macrophage OTUD1‐CARD9 axis drives isoproterenol‐induced inflammatory heart remodelling

Clinical and Translational Medicine
Background Chronic inflammation contributes to the progression of isoproterenol (ISO)‐induced heart failure (HF). Caspase‐associated recruitment domain (CARD) families are crucial proteins for initiation of inflammation in innate immunity.
Jinfu Qian, Qinyan Wang, Jiachen Xu, Shiqi Liang, Qingsong Zheng, Xiaocheng Guo, Wu Luo, Weijian Huang, Xiaohong Long, Julian Min, Yi Wang, Gaojun Wu, Guang Liang   +12 more
doaj   +1 more source

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans [PDF]

, 2018
Finck, Brian N., Franczyk, Michael, H. Liss, Kim H., Hall, Angela M., Klein, Samuel, Lutkewitte, Andrew J., Pietka, Terri, Yoshino, Jun   +7 more
core   +2 more sources

Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices

The Journal of Physiology, Volume 604, Issue 5, Page 1809-1819, 1 March 2026.
Abstract figure legend ent‐Vert selectively inhibits RyR2‐mediated sarcoplasmic reticulum (SR) Ca2+ leak and prevents triggered activity in human cardiac slices. A, in human ventricular slices exposed to β‐adrenergic stimulation with Iso and RyR2 sensitization with caffeine, RyR2 channels become hyperactive, leading to Ca2+ sarcoplasmic leak and ...
Micah K. Madrid, Katy A. Trampel, Batool Salman, Sharon A. George, Tatiana Efimova, Bjorn Knollmann, Igor R. Efimov   +6 more
wiley   +1 more source

Genetic deletion of ASIC3 alters left ventricular remodeling and autonomic function after myocardial infarction in mice

Physiological Reports, Volume 14, Issue 5, March 2026.
Abstract Cardiac afferent neurons have been shown to trigger overactivation of neurohormonal systems known to drive adverse cardiac remodeling following myocardial infarction (MI). Acid‐sensing ion channels (ASICs) that are highly expressed in cardiac sympathetic afferents sense ischemia‐induced myocardial acidosis.
Karley M. Monaghan, David D. Gibbons, Chad C. Ward, Maram El‐Geneidy, William J. Kutschke, Kathy A. Zimmerman, Donald A. Morgan, Harald M. Stauss, Anne Marie S. Harding, Michelle C. M. Bader, Peter M. Snyder, Rasna Sabharwal, Robert M. Weiss, Kamal Rahmouni, Christopher J. Benson   +14 more
wiley   +1 more source

Possible mechanism for changes in glycogen metabolism in unloaded soleus muscle [PDF]

Carbohydrate metabolism has been shown to be affected in a number of ways by different models of hypokinesia. In vivo glycogen levels in the soleus muscle are known to be increased by short-term denervation and harness suspension.
Henriksen, E. J., Tischler, M. E.
core   +1 more source

Isoproterenol [PDF]

, 2020
openaire   +1 more source

An acute temperature rise to 40°C inhibits free fatty acid uptake into white adipocytes. [PDF]

Adipocyte
Foti F, Schaepper RS, Konrad D, Wueest S.   +3 more
europepmc   +1 more source

Palmitic acid induces UCP1-independent mitochondrial depolarization specifically in brown adipose tissue. [PDF]

J Biol Chem
Ishikawa Y, Shiiba I, Kozakura E, Yabu H, Hirose S, Oshio H, Yamada KI, Okamatsu-Ogura Y, Inatome R, Yanagi S.   +9 more
europepmc   +1 more source