Results 131 to 140 of about 93,473 (332)

Effects of Intrauterine Isoproterenol Administration on Ovarian Follicular Development in Cows

open access: yesVeterinary Medicine and Science
Background Isoproterenol (ISO) is a nonselective beta‐adrenergic receptor agonist known for its vasodilatory effects. This experiment aims to investigate whether intrauterine ISO administration could alter vascular indices and follicular development in ...
Vefa Tohumcu   +7 more
doaj   +1 more source

A Novel Multiparametric Model Integrating Aortoseptal Angle to Predict the Origin of Outflow Tract Ventricular Arrhythmias

open access: yesJournal of Arrhythmia, Volume 42, Issue 1, February 2026.
The aortoseptal angle (cutoff 131.24°) effectively differentiates ventricular arrhythmia originating from the left ventricular outflow tract (LVOT). Combining the aortoseptal angle with the hypertension status and V2 transition ratio significantly improves its diagnostic accuracy.
Sunu Budhi Raharjo   +11 more
wiley   +1 more source

Supraventricular Tachycardias Using Multiple Accessory Pathways

open access: yesJournal of Arrhythmia, Volume 42, Issue 1, February 2026.
Three atrioventricular reciprocating tachycardias (AVRTs) using 3 accessory pathways (APs) occurred with the His bundle eliminated by the previous ablation. Two AVRTs using 2 right APs rotated reversely, and the other AVRT was one with a retrograde conduction through the left AP and anterograde conduction through the 2 right APs.
Takumi Yamada
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

Risk Factors for Pressure Injury in ICU Patients

open access: yesNursing Open, Volume 13, Issue 2, February 2026.
ABSTRACT Aim To investigate the specific risk factors associated with the development of hospital‐acquired pressure injuries in critically ill patients. Design A retrospective case–control study. Methods Using evidence‐based and Delphi methods, 36 potential risk factors for HAPI in critically ill patients were identified.
Yang Chaonan   +4 more
wiley   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

open access: yesThe FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati   +4 more
wiley   +1 more source

Rutin-Activated Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Attenuates Corneal and Heart Damage in Mice

open access: yesPharmaceuticals
Background: Corneal degeneration is a form of progressive cell death caused by multiple factors, such as diabetic retinopathy. It is the most well-known neural degenerative disease caused by macular degeneration in the aged and those with retinitis ...
Promise M. Emeka   +3 more
doaj   +1 more source

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79 [PDF]

open access: yes, 2001
The beta 2 adrenergic receptor (beta 2AR) undergoes desensitization by a process involving its phosphorylation by both protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs). The protein kinase A-anchoring protein AKAP79 influences beta 2AR
Chen, Wei   +8 more
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