Results 131 to 140 of about 89,475 (303)

Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the cardioprotective potential of betulin in isoproterenol (ISO)-induced myocardial injury in rats. Methods: Wistar rats were divided into five groups (n=10): normal, ISO, nebivolol 5 mg/kg, and betulin (20 & 40 mg/kg ...
Hital Shah, Tejal Gandhi
doaj   +1 more source

Myocardial Contractile Response to Norepinephrine, Isoproterenol, and Calcium Chloride in Hyperthyroid Guinea Pigs [PDF]

, 1969
M. Jay Goodkind
openalex   +1 more source

Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis

Frontiers in Pharmacology
Introduction: Isoproterenol (ISO) is regarded as an adrenergic non-selective β agonist. It regulates myocardial contractility and may cause damage to cardiac tissues.
Nuha Anajirih, Ahmed Abdeen, Ehab S. Taher, Afaf Abdelkader, Hoda A. Abd-Ellatieff, Mahmoud S. Gewaily, Nashwa E. Ahmed, Rasha H. Al-Serwi, Safwa M. Sorour, Heba M. Abdelkareem, Heba M. Abdelkareem, Elturabi Ebrahim, Mohamed El-Sherbiny, Florin Imbrea, Ilinca Imbrea, Mahmoud M. Ramadan, Mahmoud M. Ramadan, Ola A. Habotta   +17 more
doaj   +1 more source

Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart

Cell Reports, 2021
Summary: Optical methods for measuring intracellular ions including Ca2+ revolutionized our understanding of signal transduction. However, these methods are not extensively applied to intact organs due to issues including inner filter effects, motion ...
Anna Kosmach, Barbara Roman, Junhui Sun, Armel Femnou, Fan Zhang, Chengyu Liu, Christian A. Combs, Robert S. Balaban, Elizabeth Murphy   +8 more
doaj  

mTORC1 hyperactivation and resultant suppression of macroautophagy contribute to the induction of cardiomyocyte necroptosis by catecholamine surges

Physiological Reports
Previous studies revealed a controversial role of mechanistic target of rapamycin complex 1 (mTORC1) and mTORC1‐regulated macroautophagy in isoproterenol (ISO)‐induced cardiac injury.
Mingqi Cai, Penglong Wu, Wei Ni, Dong Huang, Xuejun Wang   +4 more
doaj   +1 more source

Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]

, 2019
Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core  

Rutin-Activated Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Attenuates Corneal and Heart Damage in Mice

Pharmaceuticals
Background: Corneal degeneration is a form of progressive cell death caused by multiple factors, such as diabetic retinopathy. It is the most well-known neural degenerative disease caused by macular degeneration in the aged and those with retinitis ...
Promise M. Emeka, Lorina I. Badger-Emeka, Krishnaraj Thirugnanasambantham, Abdulaziz S. Alatawi   +3 more
doaj   +1 more source

ISOPROTERENOL [PDF]

, 1966

openalex   +1 more source

The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations. [PDF]

, 2018
Conductances of ion channels and transporters controlling cardiac excitation may vary in a population of subjects with different cardiac gene expression patterns. However, the amount of variability and its origin are not quantitatively known.
Karma, Alain, Lusis, Aldons J, Rees, Colin M, Santolini, Marc, Weiss, James N, Yang, Jun-Hai   +5 more
core  

Macrophage OTUD1‐CARD9 axis drives isoproterenol‐induced inflammatory heart remodelling

Clinical and Translational Medicine
Background Chronic inflammation contributes to the progression of isoproterenol (ISO)‐induced heart failure (HF). Caspase‐associated recruitment domain (CARD) families are crucial proteins for initiation of inflammation in innate immunity.
Jinfu Qian, Qinyan Wang, Jiachen Xu, Shiqi Liang, Qingsong Zheng, Xiaocheng Guo, Wu Luo, Weijian Huang, Xiaohong Long, Julian Min, Yi Wang, Gaojun Wu, Guang Liang   +12 more
doaj   +1 more source