Results 201 to 210 of about 4,707,673 (337)

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

open access: yesAdvanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin   +12 more
wiley   +1 more source

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

open access: yesAdvanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka   +3 more
wiley   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

open access: yesAdvanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang   +14 more
wiley   +1 more source

Isothermal Oxidation Comparison of Three Ni-Based Superalloys

open access: yesJournal of materials engineering and performance (Print), 2017
H. Mallikarjuna   +2 more
semanticscholar   +1 more source

Grain Boundary Structure Ordering via Electroshock Treatment Enhances Strength‐Ductility Synergy

open access: yesAdvanced Science, EarlyView.
Electroshock treatment triggers atomic rearrangement, transforming disordered grain boundaries into ordered states without inducing recrystallization. This grain boundary ordering effectively relieves strain concentration and strengthens boundaries, enabling a simultaneous improvement in both strength and ductility.
Jiancheng Chen   +6 more
wiley   +1 more source

Orientation‐Engineered Insulator‐Metal Transition in Vanadium Dioxide

open access: yesAdvanced Science, EarlyView.
Crystallographic orientation engineering in VO2/TiO2 heterostructures enables tunable insulator‐metal transitions. The high‐Miller‐index (102) orientation breaks in‐plane mirror symmetry, inducing anisotropic transport, while its inclined oxygen channels accelerate protonation kinetics.
Xuanchi Zhou   +4 more
wiley   +1 more source

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