Results 251 to 260 of about 930,809 (352)

OsNRT1.1B‐OsCNGC14/16‐Ca2+‐OsNLP3 Pathway: Phosphorylation‐Mediated Maintenance of Nitrogen Homeostasis

open access: yesAdvanced Science, EarlyView.
OsNRT1.1B forms a membrane complex with OsCNGC14/16 that mediates nitrate‐triggered calcium influx. This calcium signal phosphorylates OsNLP3 at Ser193, accelerating its nuclear translocation and activating nitrogen‐responsive genes. The calcium‐dependent pathway complements the established ubiquitination‐mediated pathway, dynamically regulating ...
Xiaohan Wang   +9 more
wiley   +1 more source

7‐Ketodeoxycholic Acid Promotes Colonic Mucosal Healing by Inducing Calcium Release from Endoplasmic Reticulum via the TGR5‐IP3R Pathway

open access: yesAdvanced Science, EarlyView.
7‐KDCA functions by driving intestinal epithelial cell migration through induction of calcium release from the endoplasmic reticulum. The findings emphasize a previously unrecognized property of 7‐KDCA in regulating cell migration, a required process for effective epithelial restitution and repair that is particularly critical for patients with UC to ...
Jing Zhang   +9 more
wiley   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

open access: yesAdvanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang   +12 more
wiley   +1 more source

Shapes of ideal stalagmites. [PDF]

open access: yesProc Natl Acad Sci U S A
Szymczak P   +3 more
europepmc   +1 more source

Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization

open access: yesAdvanced Science, EarlyView.
Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay   +3 more
wiley   +1 more source

Synthesis of Primary Amines via Reductive Amination of Aldehydes and Ketones Over a Ni‐Doped MFM‐300(Cr) Catalyst

open access: yesAdvanced Science, EarlyView.
Reductive amination of aldehydes and ketones to primary amines with high selectivity and yield can be achieved over Ni‐doped MFM‐300(Cr) in the presence of NH3 and H2. In situ inelastic neutron scattering, coupled with modeling, reveals that cooperativity between Ni active sites and MFM‐300(Cr) affords an optimal microenvironment for the selective ...
Wenyuan Huang   +18 more
wiley   +1 more source

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