Results 31 to 40 of about 177,741 (266)

The Stalagmite Record of Southern Arabia: Climatic Extremes, Human Evolution and Societal Development

Frontiers in Earth Science, 2021
The fluctuating climatic conditions of the Saharo-Arabian deserts are increasingly linked to human evolutionary events and societal developments. On orbital timescales, the African and Indian Summer Monsoons were displaced northward and increased ...
Samuel Luke Nicholson, Matthew J. Jacobson, Rob Hosfield, Dominik Fleitmann   +3 more
doaj   +1 more source

Synthesis and Characterization of Thymine-15N2

Journal of Isotopes, 2016
A novel and mild synthesis method of thymine-15N2 was designed. Ethyl formate and ethyl propionate as raw materials, the intermediate ethyl 2-formylpropionate was condensed under sodium metal, the target compound thymine-15N2 was obtained by condensation
XU Jian-fei, DU Xiao-ning, WANG Wei, LEI Wen   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

High-Resolution in vivo Imaging of Xylem-Transported CO2 in Leaves Based on Real-Time 11C-Tracing

Frontiers in Forests and Global Change, 2019
Plant studies using the short-lived isotope 11C to label photosynthate via atmospheric carbon dioxide (CO2), have greatly advanced our knowledge about the allocation of recent photosynthate from leaves to sinks.
Michiel Hubeau, Michael R. Thorpe, Jens Mincke, Jens Mincke, Jasper Bloemen, Ingvar Bauweraerts, Peter E. H. Minchin, Veerle De Schepper, Filip De Vos, Christian Vanhove, Stefaan Vandenberghe, Kathy Steppe   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hydrogeology of salt karst under different cap soils and climates (Persian Gulf and Zagros Mts., Iran)

International Journal of Speleology, 2017
Southern Iran hosts abundant salt karst phenomena in numerous salt diapirs. This paper provides a new insight into the relationships among climate, cap soil and salt karst hydrogeology. Cave systems were documented and mapped.
Jiri Bruthans, Jiri Kamas, Michal Filippi, Mohammad Zare, Alan L. Mayo   +4 more
doaj   +1 more source

Isotopic Signatures

, 2018
© 2018 Elsevier Inc. All rights reserved. Isotopes record human influence on the Earth System, providing evidence for the Anthropocene. Lead and sulfur isotopes detail pollution histories going back millennia. Carbon and nitrogen isotopes show substantial change since the Industrial Revolution, and especially since the 1950s, related to increased ...
Dean, J.R., Leng, M.J., Mackay, A.W.
openaire   +3 more sources

ISOTOPICS – ISOTOPIC LABELING FOR DRUG INNOVATION – H2020 [PDF]

Impact, 2017
ISOTOPICS (H2020 - Marie Sklodowska-Curie Actions - Innovative Training Network; grant number 675071) combines researchers and industry in an innovative effort to de-risk drug development, create new tools for medicine and train first-class radiochemists with dual academic-industrial expertise.
Dugave, Christophe, Hinsinger, Karen
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source