Results 271 to 280 of about 48,742 (295)
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Dynamic lipidomics with stable isotope labelling
Journal of Chromatography B, 2009Incorporation of stable isotope labelled precursors enables estimation of the kinetics of lipid synthesis and turnover (dynamic lipidomics) in the clinical as well the experimental setting. Recent advances in tandem mass spectrometry extend the analytical possibilities from measurements of isotope enrichments to determinations of intact substrates ...
Postle, Anthony D., Hunt, Alan N.
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Determination of isotope distribution in labeled lysine
Analytical Biochemistry, 1974A method is described for the degradation of 14C-labeled lysine with determination of radioactivity in the individual C atoms. The method depends on permanganate oxidation of lysine to give δ-aminopentanoic acid, γ-aminobutyric acid, β-alanine, and glycine, and on ninhydrin decarboxylation of glycine.
Christensen, Ingrid Just +2 more
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Synthesis of isotopically labelled salicylates
Journal of Labelled Compounds and Radiopharmaceuticals, 1981Abstract[13C‐carboxyl]Salicylic acid has been prepared by carbonation of 2‐benzyloxybromobenzene followed by reductive debenzylation. Deuterium and tritium labelled salicylic acid and 2H2/13C‐salicylic acid were prepared by reduction of the 3,5‐dibromo derivatives using Raney Ni‐Al.
D. R. Hawkins, R. W. Pryor
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Stable Isotopic Labeling for Proteomics
2011Since the coining of the term Proteome, the field of Proteomics has developed rapidly and come to rely heavily on mass spectrometry, initially for protein identification but recently the use of stable isotopic labels for protein quantitation has grown in importance.
Ashman, Keith +3 more
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Unsupervised Identification of Isotope-Labeled Peptides
Analytical Chemistry, 2016In vivo isotopic labeling coupled with high-resolution proteomics is used to investigate primary metabolism in techniques such as stable isotope probing (protein-SIP) and peptide-based metabolic flux analysis (PMFA). Isotopic enrichment of carbon substrates and intracellular metabolism determine the distribution of isotopes within amino acids.
Igor G. L. Libourel, Joshua E. Goldford
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Hydrogen isotope labeling of PTC124
Radiochemistry, 2010PCT124 labeled with hydrogen isotopes was prepared. For efficient isotope labeling of this compound, the reaction should be performed under severe conditions. With additional supports, the isotope exchange could be performed at 260–270°C. Under these conditions, the labeled compound with the molar radio-activity of 6.5 Ci mmol-1 was prepared.
V. P. Shevchenko +2 more
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ChemInform Abstract: Isotopically Labeled Quinones [PDF]
ChemInform, 1989 M. Zielinski, M. Kanska
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Isotopic labelling of proanthocyanidins
1997International ...
Deprez, S. +3 more
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Synthesis of isotopically‐labelled ethylenethiourea
Journal of Labelled Compounds and Radiopharmaceuticals, 1990Abstract13C‐, 14C‐ and 15N‐labelled ethylenethiourea was synthesized for NMR and radiotracer applications in metabolism and environmental fate studies. The products contained stable isotopes at 99% enrichment and the radiolabelled product had specific activity of 2.0 mCi/mmole.
Walter P. Niemczura +3 more
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Reductive methods for isotopic labeling of antibiotics
Analytical Biochemistry, 1989Methods for the reductive methylation of the amino groups of eight different antibiotics using 3HCOH or H14COH are presented. The reductive labeling of an additional seven antibiotics by NaB3H4 is also described. The specific activity of the methyl-labeled drugs was determined by a phosphocellulose paper binding assay. Two quantitative assays for these
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