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Isotopic labelings for mechanistic studies

The intricate mechanisms in the biosynthesis of terpenes belong to the most challenging problems in natural product chemistry. Methods to address these problems include the structure-based site-directed mutagenesis of terpene synthases, computational approaches, and isotopic labeling experiments. The latter approach has a long tradition in biosynthesis
Houchao, Xu, Jeroen S, Dickschat
openaire   +2 more sources

Production of Isotopically Labeled KRAS4b

Isotopically labelled proteins are important reagents in structural biology as well as in targeted drug development. The field continues to advance with complex multi-isotope labeling. We have combined our experience in high-level soluble KRAS4b expression with protocols for isotope incorporation, to achieve reliable and efficient approaches for ...
Troy, Taylor, William, Gillette
openaire   +2 more sources

ICPL—Isotope-Coded Protein Label

2008
Stable isotope labeling in combination with mass spectrometry has emerged as a powerful tool to identify and relatively quantify thousands of proteins within complex protein mixtures. Here we describe a method, termed isotope-coded protein label (ICPL), which is capable of high-throughput quantitative proteome profiling on a global scale.
openaire   +3 more sources

Carboxylic Acid Salts as Dual‐Function Reagents for Carboxylation and Carbon Isotope Labeling

Angewandte Chemie - International Edition, 2023
Gregory J P Perry   +2 more
exaly  

Isotopic labelling of proanthocyanidins

1997
International ...
Deprez, S.   +3 more
openaire   +1 more source

Radiopharmaceuticals labelled with bromine isotopes

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1986
B, Maziere, C, Loc'h
openaire   +2 more sources

Recent advances in stable isotope labeling based techniques for proteome relative quantification

Journal of Chromatography A, 2014
Yichu Shan, Xudong Zhu, Yuan Zhou
exaly  

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