Results 231 to 240 of about 792,425 (354)

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

open access: yesAdvanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu   +9 more
wiley   +1 more source

Heavy boron isotopes in intraplate basalts reveal recycled carbonate in the mantle. [PDF]

open access: yesSci Adv
Xu R   +11 more
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

open access: yesAdvanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen   +6 more
wiley   +1 more source

Mechanism of lateral cell-wall expansion at a constant diameter in Bacillus subtilis. [PDF]

open access: yesNat Commun
Liang Y   +6 more
europepmc   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

open access: yesAdvanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez   +20 more
wiley   +1 more source

Passive degassing of lithospheric volatiles recorded in shallow young groundwater. [PDF]

open access: yesNat Geosci
Tyne RL   +8 more
europepmc   +1 more source

Sustainable Electrochemical Strategy for Selective Double Bond Oxidation in the Presence of Aldehyde Groups with Mo─N─O Catalysts

open access: yesAdvanced Science, EarlyView.
In this work, an electrochemical strategy employing hydroperoxyl radicals and a molybdenum‐based catalyst (Mo─N─O) enables selective double‐bond oxidation in cinnamaldehyde, preserving aldehyde integrity. Under mild, energy‐efficient conditions (−200 mA), this approach converts cinnamaldehyde to benzaldehyde with complete conversion (100%) and >99 ...
Zhirong Li   +12 more
wiley   +1 more source

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