Results 191 to 200 of about 104,171 (282)

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source

Mechanistic Divergence in Sulfur‐Ligated Iron(III)‐Alkylperoxo Reactivity: Aldehyde Oxidation Prevails over Deformylation

Angewandte Chemie, EarlyView.
This study explores the mechanistic investigation into an unusual reactivity of a thioether‐ligated low‐spin Fe(III)‐alkylperoxide with cyclohexane–carboxaldehyde as a mimic of nonheme iron(II) enzyme intermediates and highlights that only efficient catalysis happens from a high‐valent iron(IV)‐oxo species.
Jagnyesh K. Satpathy, Rolly Yadav, Payal Panwar, Vijaya Thangaraj, Maheswaran Shanmugam, Chivukula V. Sastri, Sam P. de Visser   +6 more
wiley   +2 more sources

Dietary ecology of the endangered seahorse Hippocampus haema unveiled through stable isotope analysis. [PDF]

Sci Rep
Kim MJ, Kim JS, Lee YJ, Park JM, Kwak SN, Shin D, Lee SH.   +6 more
europepmc   +1 more source

Tri‐Modal Anticancer Strategies with Doxorubicin‐Loaded Iron Oxide Nanoparticles Integrating Chemo and Magneto‐Photothermal Therapeutic Effects

Advanced NanoBiomed Research, EarlyView.
Maghemite nanoparticles functionalized with doxorubicin enable synergistic chemo‐magneto‐photothermal therapy. Combining pH‐sensitive drug release with localized heating at clinically relevant low doses enhances tumor cell death while minimizing toxicity.
Rosalía López‐Méndez, Nuria Lafuente‐Gómez, Eva Céspedes, Mónica Dhanjani, Marina París‐Ogáyar, Francisco José Terán, Aida Serrano, Julio Camarero, Gorka Salas, Claire Wilhelm, Álvaro Somoza, Ana Espinosa   +11 more
wiley   +1 more source

Cold‐Captured Dynamic Hydration Networks in Oxime‐Based Photoswitches: A Theoretical Challenge Uncovered by Rotational Spectroscopy

Angewandte Chemie, EarlyView.
By combining gas‐phase rotational spectroscopy and quantum chemistry calculations, we explore how a prototype molecular photoswitch is affected by microhydration. This study unveils the theory‐breaking structural features of camphorquinone oxime, the concerted dynamics of the surrounding water network, and how the oxime subunit actively steers the ...
Rita J. C. Roque, Nuno M. Campos, Marcos Gouveia, Sérgio R. Domingos   +3 more
wiley   +2 more sources

Reconstructing medieval diets through the integration of stable isotope and proteomic analyses from two European burial sites. [PDF]

Sci Rep
Pedergnana A, Grossmann J, Turck R, Goujon A, Rühli F, Wilkin S, Eppenberger P, Lehn C.   +7 more
europepmc   +1 more source

NIR‐Activatable, Sequence‐Specific Metal‐Nucleic Acid Scaffolds for Responsive Uncaging

Angewandte Chemie, EarlyView.
We demonstrate that long‐range nucleic acid‐mediated electron transfer can drive Pt(IV) photoreduction, establishing a new class of metal‐nucleic acid scaffolds capable of “responsive uncaging,” where hybridization with target DNA or miRNA directly triggers payload release under NIR irradiation.
Arpit Sharma, Man Kshetri, Deepak Karna, Md Al Amin, Shirin Akter, Hanbin Mao, Yao‐Rong Zheng   +6 more
wiley   +2 more sources

Vanadium-Mediated Carbon Isotope Exchange of Terminal Alkenes. [PDF]

J Am Chem Soc
Krivovicheva V, Gangireddy MSR, Liu A, Maya LB, Mebel AM, Bukhryakov KV.   +5 more
europepmc   +1 more source

Materials Innovation and the Changing Face of Photocatalytic and Electrocatalytic Carbon Dioxide Reduction Research: From Metal Nanoclusters to Extended Frameworks

Angewandte Chemie, EarlyView.
Innovative catalyst design is advancing precision‐controlled catalysis for CO2 reduction. This minireview investigates the forefront of photocatalytic and electrocatalytic CO2 reduction (CO2RR) leveraging metal nanoclusters (NCs), metal–organic frameworks (MOFs), and covalent organic frameworks (COFs), concentrating on structure–activity correlations ...
Tsukasa Irie, Kohki Sasaki, Saikat Das, Yuichi Negishi   +3 more
wiley   +2 more sources

What the earliest evidence for life tells us about the early evolution of the biosphere. [PDF]

Philos Trans R Soc Lond B Biol Sci
Westall F.
europepmc   +1 more source