Results 181 to 190 of about 121,467 (287)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg   +7 more
wiley   +1 more source

Geographical traceability of bacteria based on a systematic stable isotope analysis method. [PDF]

open access: yesAppl Microbiol Biotechnol
Wang W   +11 more
europepmc   +1 more source

Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT To advance understanding of cellular metabolism and reduce batch‐to‐batch variability in cell culture processes, this study introduces a multi‐scale hybrid modeling framework designed to simulate and predict the dynamic behavior of CHO cell cultures undergoing metabolic phase transitions.
Keqi Wang, Sarah W. Harcum, Wei Xie
wiley   +1 more source

Mechanistic elucidation of HFIP‐enabled C–Cl bond activation in the synthesis of tetrahydroquinoline derivatives

open access: yesBulletin of the Korean Chemical Society, EarlyView.
Mechanistic studies reveal that hexafluoroisopropanol (HFIP) enables C–Cl activation of propargylic halides by stabilizing ion pairs and enhancing effective Brønsted acidity. This cooperative solvent effect allows access to cationic intermediates and promotes cascade formation of tetrahydroquinolines through cyclization and disproportionation ...
Seung Hoon Lee, Hyung Min Chi
wiley   +1 more source

Classifying avian drinking behaviour: ecological insights and implications in a changing world

open access: yesBiological Reviews, EarlyView.
ABSTRACT Water is a fundamental currency of life, and its availability significantly influences animal behaviour, physiology and distributions. However, our knowledge around the dependence on water for drinking and the direct and indirect mechanisms driving related behaviours remains partial in the context of changing climates. Here, we review patterns
Shannon R. Conradie, Marc T. Freeman
wiley   +1 more source

Ruthenium‐Based Catalysts Supported on Lanthanum and Carbon‐Modified Alumina for Low‐Pressure Ammonia Synthesis

open access: yesCarbon and Hydrogen, EarlyView.
We proposed a new “hydrogen transfer–desorption” synergistic regulation strategy and developed a Ru/Al2O3‐La‐C catalyst with dual functions. La‐O sites were constructed and carbon components were introduced into the catalyst to regulate the two key steps of hydrogen transfer and desorption on the catalyst surface, respectively, solving the problem of ...
Xiang Li   +3 more
wiley   +1 more source

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