Results 91 to 100 of about 69,048 (265)

Discussion on the need for correction during isotopic analysis of nitrogen by the denitrifier method. [PDF]

RSC Adv, 2023
Hu J, Pan M, Li Y, Xing M, Cao Y, Yang K, Liu W.   +6 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Connected in diversity: Isotopic analysis refines provenance for Islamic plant-ash glass from the eastern Silk Roads. [PDF]

iScience, 2023
Lü QQ, Basafa H, Henderson J.
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Tracking the British agricultural revolution through the isotopic analysis of dated parchment. [PDF]

Sci Rep, 2023
Doherty SP, Alexander MM, Henderson S, Newton J, Finch J, Collins MJ.   +5 more
europepmc   +1 more source

isotope exchange analysis

, 2014
Citation: 'isotope exchange analysis' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.I03329 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Blockchain-based isotopic big data-driven tracing of global PM sources and interventions

Nature Communications
Tracing sources and assessing intervention effectiveness are crucial for controlling atmospheric particulate matter (PM) pollution. Isotopic techniques enable precise top-down tracing, but the absence of long-term, global-scale multi-compound isotopic ...
Yuming Huang, Xiangyu Li, Yuehan Wu, Chaoyang Xue, Jiashuo Li, Yongfeng Lin, Wei Nie, Xian Liu, Qian Liu, Greg Michalski, Jingwei Zhang, Zheng Zong, Dawei Lu, Guibin Jiang   +13 more
doaj   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Strontium–Neodymium isotopic compositions of eighteen geological Chinese reference materials measured on TIMS and MC-ICP-MS

Solid Earth Sciences
This study presents radiogenic Sr–Nd isotopic compositions of eighteen geological Chinese reference materials (RMs) measured on TIMS and MC-ICP-MS independently.
Wenke Wang, Jiaojiao Wu, Fang Liu, Xin Li, Yajun An, Zhaofeng Zhang   +5 more
doaj   +1 more source