Results 261 to 270 of about 32,281 (298)

In-silico design, ADMET screening, MM-GBSA binding free energy of some novel isoxazole substituted 9-anilinoacridines as HER2 inhibitors targeting breast cancer.

Current Drug Research Reviews, 2019
BACKGROUND Human epidermal development factor receptor-2 (HER2) is the dominent Tyrosine kinase receptor, being enhanced in 20% of instances of breast cancer.
R. Kalirajan, A. Pandiselvi, B. Gowramma, Pandiyan Balachandran   +3 more
semanticscholar   +1 more source

An Isoxazole Strategy for the Synthesis of α-Aminopyrrole Derivatives.

Journal of Organic Chemistry, 2019
A synthesis of methyl 5-aminopyrrole-3-carboxylates from 4-methyleneisoxazol-3-ones via "cyanide Michael addition/methylation/reductive isoxazole-pyrrole transformation" is developed.
E. Galenko, S. Linnik, O. Khoroshilova, M. Novikov, A. Khlebnikov   +4 more
semanticscholar   +1 more source

Application, Reactivity and Synthesis of Isoxazole Derivatives

Mini-Reviews in Organic Chemistry, 2020
In this review article, we describe the application, reactivity and synthesis of isoxazole derivatives, more specifically, the application, reactivity, and synthesis of 3,5-disubstituted, 3,4- disubstituted, and 3,4,5-trisubstituted isoxazole using the
Yogesh S Walunj, P. Mhaske, P. Kulkarni
semanticscholar   +1 more source

The coordination chemistry of isoxazoles

Coordination Chemistry Reviews, 1991
Isoxazole-metal complexes are often postulated as intermediates in reactions of considerable synthetic utility, for example the reductive ring opening of isoxazoles. Several isoxazole-metal complexes have been reported and well characterized. However, an updated review of this chemistry is needed.
Mark S. Munsey, Nicholas R. Natale
openaire   +2 more sources

Recent Developments in Isoxazole Chemistry

1963
Publisher Summary This chapter reviews new investigations in the field of synthetic isoxazoles. Isoxazoles possess the properties of the aromatic system. The syntheses of isoxazole derivatives involving formation of the 1–5 and 2–3 bonds of the isoxazole ring, as well as formation of the 1–5 and 3–4 bonds of the ring are described in the chapter. The
Nikolay K. Kochetkov, S.D. Sokolov
openaire   +3 more sources

Structure of an isoxazole amino ester

Acta Crystallographica Section C Crystal Structure Communications, 1991
2'-(N-Methylamino)-2-methylpropyl 5-methyl-3-phenylisoxazole-4-carboxylate hydroiodide, C16H21N2O3+.I-, Mr = 416.26, orthorhombic, Pna21, a = 23.293 (7), b = 10.276 (3), c = 7.971 (1) A, V = 1908.0 (8) A3, Z = 4, Dx = 1.448 g cm-3, Mo K alpha, lambda = 0.71069 A, mu = 17.1 cm-1, F(000) = 832, T = 293 K, R = 0.0610 for 1846 unique observed reflections ...
Yousef R. Mirzaei, Brian L. Scott, Miles P. Smith, R. D. Willett, Nicholas R. Natale   +4 more
openaire   +3 more sources

Design, synthesis, antileishmanial, and antifungal biological evaluation of novel 3,5‐disubstituted isoxazole compounds based on 5‐nitrofuran scaffolds

Archiv der Pharmazie, 2019
Nineteen 3,5‐disubstituted‐isoxazole analogs were synthesized based on nitrofuran scaffolds, by a [3 + 2] cycloaddition reaction between terminal acetylenes and 5‐nitrofuran chloro‐oxime. The compounds were obtained in moderate to very good yields (45–91%
Ozildéia S. Trefzger, Natália V Barbosa, Renata L Scapolatempo, A. D. das Neves, Maria L F S Ortale, Diego B. Carvalho, A. M. Honorato, Mariana R Fragoso, Cristiane Y K Shuiguemoto, R. Perdomo, M. D. F. Matos, M. Chang, C. Arruda, A. Baroni   +13 more
semanticscholar   +1 more source

Fragmentation mechanisms of isoxazole

Organic Mass Spectrometry, 1981
AbstractFragmentation pathways of isoxazole giving ions [C3H2ON]+, [C2H3N]+˙ and [C2H2N]+ are elucidated by means of metastable ion studies and thermodynamic properties. Rearrangement reactions are demonstrated to occur with H and HCO loss. Elimination of carbon monoxide leads to [C2H3N]+˙ ions whose reacting configuration is the same as for ...
Yannik Hoppilliard, Guy Bouchoux
openaire   +2 more sources

Harnessing the TEMPO catalyzed aerobic oxidation for Machetti-DeSarlo reaction towards sustainable synthesis of isoxazole libraries.

Journal of Organic Chemistry, 2019
A practical synthesis of isoxazole/isoxazoline derivatives via Machetti-DeSarlo reaction under sustainable conditions has been accomplished. This protocol involves the use of readily available TEMPO to catalyze the cyclocondensation of prima-ry ...
M. Vadivelu, S. Sampath, K. Muthu, K. Karthikeyan, C. Praveen   +4 more
semanticscholar   +1 more source

Molecular docking studies and biological evaluation of isoxazole-carboxamide derivatives as COX inhibitors and antimicrobial agents

3 Biotech, 2022
Mohammed Hawash, N. Jaradat, M. Abualhasan, Mohammed T Qaoud, Yara Joudeh, Z. Jaber, Majd Sawalmeh, Abdulraziq Zarour, A. Mousa, Mohammed Arar   +9 more
semanticscholar   +1 more source